Ya-ting Yang

From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors.

Jiuxiang Zhu, Jui-Wen Huang, +6 authors Ching-Shih Chen
Cancer research
2004

The blockade of Akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (PDK-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. Celecoxib, however,… (More)

3-phosphoinositide-dependent protein kinase-1/Akt signaling represents a major cyclooxygenase-2-independent target for celecoxib in prostate cancer cells.

Samuel K. Kulp, Ya-ting Yang, +6 authors Ching-Shih Chen
Cancer research
2004

Regarding the involvement of cyclooxygenase-2 (COX-2)-independent pathways in celecoxib-mediated antineoplastic effects, the following two issues remain outstanding: identity of the non-COX-2 targets… (More)

Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells.

Xueqin Song, Ho-Pi Lin, +4 authors Ching-Shih Chen
Journal of the National Cancer Institute
2002

BACKGROUND The antitumor activity of cyclooxygenase-2 (COX-2) inhibitors is thought to involve COX-2 enzyme inhibition and apoptosis induction, but it is unclear whether COX-2 inhibition is required… (More)

Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells.

Jui-Wen Huang, Chung-Wai Shiau, +5 authors Ching-Shih Chen
Molecular pharmacology
2005

In light of the clinical relevance of targeting cyclin D1 in breast cancer, we have investigated the mechanism underlying the effect of the peroxisome proliferator-activated receptor-gamma… (More)

Peroxisome Proliferator-Activated Receptor γ-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells

Jui-Wen Huang, C. W. Shiau, +5 authors Ching-Shih Chen
2005

In light of the clinical relevance of targeting cyclin D1 in breast cancer, we have investigated the mechanism underlying the effect of the peroxisome proliferator-activated receptor-γ (PPARγ)… (More)

Bcl-xL mediates a survival mechanism independent of the phosphoinositide 3-kinase/Akt pathway in prostate cancer cells.

Chih-Cheng Ou Yang, Ho-Pi Lin, +4 authors Ching-Shih Chen
The Journal of biological chemistry
2003

Among various molecular strategies by which prostate cancer cells evade apoptosis, phosphoinositide 3-kinase (PI3K)/Akt signaling represents a dominant survival pathway. However, different prostate… (More)

Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection.

Hsiang-Yin Lin, Ya-ting Yang, +4 authors Yen-Hung Chow
Journal of virology
2013

Enterovirus 71 (EV71) causes hand, foot, and mouth disease and severe neurological disorders in children. Human scavenger receptor class B member 2 (hSCARB2) and P-selectin glycoprotein ligand-1… (More)

Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel–Lindau-dependent pathway

Ching-Hao Li, P Liao, +4 authors Jaw-Jou Kang
Archives of Toxicology
2013

Hypoxia-mediated stress responses are important in tumor progression, especially when tumor growth causes the tumor to become deprived of its blood supply. The oxygen-labile transcription factor… (More)

Peroxisome Proliferator-Activated Receptor-Independent Ablation of Cyclin D 1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells

Jui-Wen Huang, Chung-Wai Shiau, +5 authors Ching-Shih Chen
2005

In light of the clinical relevance of targeting cyclin D1 in breast cancer, we have investigated the mechanism underlying the effect of the peroxisome proliferator-activated receptor(PPAR ) agonists… (More)

Mechanism and inhibition of hypochlorous acid-mediated cell death in human monocyte-derived macrophages.

Ya-ting Yang
2010

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