Ya. Sh. Shvarts

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OBJECTIVES Despite advances in systemic lupus erythematosus (SLE) treatment, many patients suffer from the disease and side effects. Atacicept is a fusion protein that blocks B-lymphocyte stimulator and a proliferation-inducing ligand, which are increased in patients with SLE. METHODS In this double-blind, placebo-controlled study, patients with(More)
BACKGROUND Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. METHODS AND RESULTS In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial(More)
One of the main mechanisms in the pathogenesis of toxic liver damage is destabilization of the membranes of hepatocytes as a result of lipid peroxidation (LPO). In the case of such liver disorders, a pronounced protective action is offered by phenolic antioxidants such as -tocopherol [1], potassium phenosane, synthetic derivatives of hydroxycynnamic acids,(More)
The development of cirrhosis of the liver is largely dependent on functional activity of organotypic macrophages and the mononuclear phagocyte system (MPS) as a whole [2]. There are indications in the literature of the depressed functional activity of the liver macrophages (Kupffer cells) in cirrhosis [i]. At the same time, we do not know how the functional(More)
Preincubation of resident macrophages with 25-hydroxycholesterol decreased the lipopolysaccharide-induced expression of mRNAs of tumor, necrosis factor and interleukin-1, while 7-ketocholesterol stimulated the expression of the tumor necrosis factor mRNA. Tolerant macrophages characterized by decreased tumor necrosis factor secretion in response to(More)
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