Learn More
The Kruppel-associated box (KRAB)-associated co-repressor KAP1 is an essential nuclear co-repressor for the KRAB zinc finger protein superfamily of transcriptional factors. Ataxia telangiectasia mutated (ATM)-Chk2 and ATM- and Rad3-related (ATR)-Chk1 are two primary kinase signaling cascades activated in response to DNA damage. A growing body of evidence(More)
Astrocytes are critical in synapse development, and their dysfunction in crucial developmental stages leads to serious neurodevelopmental diseases, including seizures and epilepsy. Immune challenges not only affect brain development, but also promote seizure generation and epileptogenesis, implying immune activation is one of the key factors linking(More)
Nuclear factor kappa-beta (NF-κB) is a critical transcription factor modulating the expression of many genes involved in the pathogenesis of psoriasis. SUMO4 is a negative regulator of NF-κB in the cell-signaling pathway. Two functional polymorphisms of the NFKB1 and SUMO4 genes have been found to be associated with the risks of some autoimmune-related(More)
This article retrospectively analyzed 2 cases of multiple myeloma (MM) with onset from coagulation disorder, and reviewed the similar cases in literatures. 2 patients all exhibited skin and mucosal bleeding as the first symptom, among who one case exhibited extended prothrombin time (PT) and thrombin time, increased D-dimer quantitation, reduced clotting(More)
  • 1