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Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. Psoriasis is currently thought of as a T-cell mediated 'Type-1' autoimmune disease. Gene expression changes in psoriasis lesions have been well documented, and strongly support an important role for(More)
The genetic feature of zebrafish is similar to that of mammal, which renders zebrafish an emerging animal model for biotechnology. A recently discovered circularly permuted yellow fluorescent protein (cpYFP) is a superoxide-specific indicator. We specifically transfect the cpYFP into the liver of zebrafish and use a fiber-optic fluorescent probe to conduct(More)
Superoxide anion is the key radical that causes intracellular oxidative stress. The lack of a method to directly monitor superoxide concentration in vivo in real time has severely hindered our understanding on its pathophysiology. We made transgenic zebrafish to specifically express yellow fluorescent proteins, a reversible superoxide-specific indicator, in(More)
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