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Protoapigenone, a natural derivative of the flavonoid apigenin, has been shown to exhibit potent antitumor activity in vitro and in vivo; the precise mechanism of action, however, is not fully elucidated. In this study, we investigated and compared the mechanisms by which protoapigenone and apigenin caused cell death in the human breast cancer MDA-MB-231(More)
Methadone (Mtd) is a widely used opioid drug associated with the side effect of hyperprolactinemia. The mechanism of how Mtd induces prolactin secretion remains unclear. The effects of Mtd and its two main metabolites (EDDP: (±)-2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium percholarate and EMDP: 2-ethyl-5-methyl-3,3-dipnehyl-1-pyrroline) on ion currents(More)
In this study, an attempt was made to elucidate the effects of thymol, a monocyclic phenolic compound, on Ca2+ mobilization and ion currents in pituitary GH3 cells with the aid of fura-2 fluorimetry and the whole-cell voltage-clamp technique. Thymol increased intracellular Ca2+ concentrations ([Ca2+]i) in GH3 cells loaded with Ca2+-sensitive dye fura-2.(More)
Investigation of the leaves' extract of Cinnamomum tenuifolium (Lauraceae) led to the isolation of one novel benzodioxocinone, 2,3-dihydro-6,6-dimethylbenzo-[b][1,5]dioxocin-4(6 H)-one (1). The structure was determined through in-depth spectroscopic and mass-spectrometric analyses. The antioxidant potential was evaluated using the following in vitro method:(More)
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The(More)
Red pepper, Capsicum annuum (Solanaceae), is used as a spice all over the world. Red pepper is studied actively because its pungent principal component, capsaicin, has a dietary effect, analgesic activity, and antioxidant activity [1]. The pungent principal component of red peppers is a group of acid amides of vanillylamine and C8 to C13 fatty acids, which(More)
Red pepper, Capsicum annuum (Solanaceae), is used as a spice all over the world. Red pepper is widely studied because its pungent principal component, capsaicin, has dietary, analgesic, and antioxidant activities [1]. The pungent principal component of red peppers is a group of acid amides of vanillylamine and C8 to C13 fatty acids, which are known(More)
Champacaine (1), (–)-anonaine (2), (–)-norushinsunine (3), (–)-ushinsunine (4), (–)-N-acetylanonaine (5), (–)-roemerine (6), (–)-asimilobine (7), (–)-anolobine (8), (–)-isocorydine (9), liriodenine (10), atherospermidine (11), O-methylmoschatoline (12), (+)-syringaresinol (13), N-trans-feruloyltyramine (14), 4-hydroxybenzaldehyde (15), vanillin (16),(More)
Lignum Aquilariae Resinatum has been widely used in the treatment of various kinds of pain, cough, and anaphylaxis for hundreds of years in Asia, especially in China, Vietnam, and Indonesia. The genus Aquilaria (Thymelaeaceae) is widely distributed in Asia. Aquilaria sinensis Gilg is of particular interest economically because it is the principal source of(More)
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