Ya-Chen Liu

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Three new butanolides, kotomolide A (1), isokotomolide A (2), and kotomolide B (3), and a new secobutanolide, secokotomolide A (4), along with 21 known compounds were isolated from the leaves of Cinnamomum kotoense. Their structures were determined by spectroscopic analyses. Compound 4 was found to induce significant cell death in the human HeLa cell line.(More)
Saikosaponin C is one of the saikosaponins that are consisted in a Chinese herb, Radix Bupleuri. Recently, saikosaponins have been reported to have properties of cell growth inhibition, inducing cancer cells differentiation and apoptosis. However, saikosaponin C had no correlation with cell growth inhibition. In this study, we investigated the role of(More)
Sevoflurane is an inhalation anesthetic used for general anesthesia. Several studies have demonstrated that reactive oxygen species (ROS) exist in cardioprotection when preconditioned with sevoflurane. Moreover, sevoflurane can also directly trigger the formation of peroxynitrite. Up to now, information pertinent to the effect of sevoflurane on cellular(More)
Hyperbaric oxygen (HBO) is increasingly used in a number of areas of medical practice, such as selected problem infections and wounds. The beneficial effects of HBO in treating ischemia-related wounds may be mediated by stimulating angiogenesis. We sought to investigate VEGF, the main angiogenic regulator, regulated by HBO in human umbilical vein(More)
The Wnt/β-catenin pathway has been implicated in leukemogenesis. We found β-catenin abnormally accumulated in both human acute T cell leukemia Jurkat cells and human erythroleukemia HEL cells. β-Catenin can be significantly down-regulated by the Janus kinase 2 specific inhibitor AG490 in these two cells. AG490 also reduces the luciferase activity of a(More)
The type-I plasminogen activator inhibitor (PAI-1), the primary inhibitor of both tissue-type and urokinase-type plasminogen activators (t-PA, u-PA), is the primary regulator of plasminogen activation and possibly of extracellular proteolysis. In anchorage-dependent cells, the PAI-1 gene is regulated by cell adhesion. PAI-1 gene expression is induced more(More)
One of the biological effects of hyperbaric oxygen (HBO) therapy in enhancing ischemia-related wound healing is the induction of angiogenesis. To elucidate the mechanism(s) underlying the HBO-induced angiogenesis, we studied the expression of several angiogenesis-related genes in human umbilical vein endothelial cells exposed to HBO. Western blot analyses(More)
The principle of chaotic BP neural network is described, the control strategy of annealing strategy is introduced so as to control the chaotic movement during the later training, and some related conclusions are proved. Then, the implement steps of chaotic BP neural network based case retrieval (CR/CBPNN) method are introduced. An improved Delphi approach(More)
Compared with regulation-weight baseballs, lightweight baseballs generate lower torque on the shoulder and elbow joints without altering the pitching movement and timing. This study investigates the throwing accuracy, throwing velocity, arm swing velocity, and maximum shoulder external rotation (MSER) of adolescent players after 10 weeks of pitching(More)
The purpose of this study was to investigate the effects of the 8-week dynamic moment of inertia (DMOI) bat training on swing velocity, batted-ball speed, hitting distance, muscle power, and grip force. The DMOI bat is characterized in that the bat could be swung more easily by reducing the moment of inertia at the initial stage of swing without decreasing(More)