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Raf-1 kinase inhibitory protein (RKIP), an endog-enous inhibitor of the extracellular signal-regulated kinase (ERK) pathway, suppresses metastasis in a number of cancer types, including colorectal carcinoma (CRC); thus, RKIP downregulation significantly contributes to CRC invasive-ness and metastatic potential. However, our previous study demonstrated that(More)
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