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CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
TLDR
In vivo as well as ex vivo genome editing using adeno-associated virus, lentivirus, or particle-mediated delivery of guide RNA in neurons, immune cells, and endothelial cells is demonstrated, suggesting that Cas9 mice empower a wide range of biological and disease modeling applications. Expand
Systematic comparison of 2A peptides for cloning multi-genes in a polycistronic vector
TLDR
The effect of varying gene position and 2As on the expression of proteins encoded in bi-, tri-, or quad-cistronic constructs is characterized and results on protein expression ratios from different 2A constructs could serve to guide future utilization of 2A peptides in basic research and clinical applications. Expand
Role of breast regression protein-39 in the pathogenesis of cigarette smoke-induced inflammation and emphysema.
TLDR
A novel regulatory role of BRP-39/YKL-40 in CS-induced inflammation and emphysematous destruction is demonstrated and it is underscored that maintaining physiologic concentrations of YKL -40 in the lung is therapeutically important in preventing excessive inflammatory responses or emphySEmatous alveolar destruction. Expand
Single Cell Transcriptomics Reconstructs Fate Conversion from Fibroblast to Cardiomyocyte
TLDR
Single-cell transcriptomics approaches enabled us to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in iCM induction. Expand
Local spatial and temporal factors influencing population and societal vulnerability to natural disasters.
TLDR
Investigations of county-level spatial and temporal patterns in social vulnerability in China from 1980 to 2010 demonstrate that the dynamic characteristics of China's county- level social vulnerability are notably distinct, and the dominant contributors to societal vulnerability for all of the years studied were rural character, development (urbanization), and economic status. Expand
Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors.
TLDR
Exercise led to improvement in AI-induced arthralgia in previously inactive breast cancer survivors and pain severity and interference decreased significantly at 12 months in women randomly assigned to exercise, compared with increases for those receiving usual care. Expand
Scientific Advances in Lung Cancer 2015
TLDR
The International Association for the Study of Lung Cancer has gathered experts in different areas of lung cancer research and management to summarize the most significant scientific advancements related to prevention and therapy of Lung cancer during the past year. Expand
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.
TLDR
It is reported that the DNMT3A mutational hotspot at Arg882 (DNMT 3A(R882H)) cooperates with NRAS mutation to transform hematopoietic stem/progenitor cells and induce acute leukemia development. Expand
Re-patterning of H3K27me3, H3K4me3 and DNA methylation during fibroblast conversion into induced cardiomyocytes.
TLDR
The data suggest early rapid activation of the cardiac program and later progressive suppression of fibroblast fate at both epigenetic and transcriptional levels, and could provide future genome-wide epigenetic studies with important guidance such as the appropriate time window and loci to be utilized as positive and negative controls. Expand
Traditional Chinese medicine for treatment of liver diseases: progress, challenges and opportunities
TLDR
TCM herbal preparations from the Chinese materia medica (such as Fuzheng Huayu) that are typically used for the treatment of liver diseases are introduced and it is proposed that side effects of herbal compounds are often under-appreciated. Expand
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