• Publications
  • Influence
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
  • W. Sun, Y. Li, +7 authors Z. Jiang
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 26 May 2009
We report here the identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN stimulator, which is a strong type I IFN stimulator and plays a pivotal role in responseExpand
  • 454
  • 33
  • Open Access
Treatment of HCV infection by targeting microRNA.
BACKGROUND The stability and propagation of hepatitis C virus (HCV) is dependent on a functional interaction between the HCV genome and liver-expressed microRNA-122 (miR-122). Miravirsen is a lockedExpand
  • 1,612
  • 23
  • Open Access
Genetic analysis of cavefish reveals molecular convergence in the evolution of albinism
The genetic basis of vertebrate morphological evolution has traditionally been very difficult to examine in naturally occurring populations. Here we describe the generation of a genome-wide linkageExpand
  • 425
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  • Open Access
The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival
Gfi1 was first identified as causing interleukin 2-independent growth in T cells and lymphomagenesis in mice. Much work has shown that Gfi1 and Gfi1b, a second mouse homolog, play pivotal roles inExpand
  • 212
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  • Open Access
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
Mutations in the gene parkin in humans (PARK2) are responsible for a large number of familial cases of autosomal-recessive Parkinson disease. We have isolated a Drosophila homolog of human PARK2 andExpand
  • 384
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  • Open Access
Quantitation of DNA double-strand break resection intermediates in human cells
5′ strand resection at DNA double strand breaks (DSBs) is critical for homologous recombination (HR) and genomic stability. Here we develop a novel method to quantitatively measure single-strandedExpand
  • 131
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  • Open Access
STAT5 programs a distinct subset of GM-CSF-producing T helper cells that is essential for autoimmune neuroinflammation
T helper (TH)-cell subsets, such as TH1 and TH17, mediate inflammation in both peripheral tissues and central nervous system. Here we show that STAT5 is required for T helper-cell pathogenicity inExpand
  • 115
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The zebrafish van gogh mutation disrupts tbx1, which is involved in the DiGeorge deletion syndrome in humans
The van gogh (vgo) mutant in zebrafish is characterized by defects in the ear, pharyngeal arches and associated structures such as the thymus. We show that vgo is caused by a mutation in tbx1, aExpand
  • 193
  • 16
  • Open Access
A mRNA localized to the vegetal cortex of Xenopus oocytes encodes a protein with a nanos-like zinc finger domain.
mRNAs concentrated in specific regions of the oocyte have been found to encode determinants that specify cell fate. We show that an intermediate filament fraction isolated from Xenopus stage VIExpand
  • 270
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  • Open Access
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia: Time to Move Toward a Minimal Residual Disease-Based Definition of Complete Remission?
PURPOSE Patients with acute myeloid leukemia (AML) who are in morphologic complete remission are typically considered separately from patients with active disease (ie, ≥ 5% marrow blasts byExpand
  • 184
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  • Open Access