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CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling
Mutations in cyclin-dependent kinase-like 5 (CDKL5), also known as serine/threonine kinase 9 (STK9), have been identified in patients with Rett syndrome (RTT) and X-linked infantile spasm. However,Expand
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  • Open Access
Activity-Dependent Development of Callosal Projections in the Somatosensory Cortex
The corpus callosum is the largest commissural system in the mammalian brain, but the mechanisms underlying its development are not well understood. Here we report that neuronal activity is necessaryExpand
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  • Open Access
“Kiss-and-Run” Glutamate Secretion in Cultured and Freshly Isolated Rat Hippocampal Astrocytes
Under physiological conditions, astrocytes not only passively support and nourish adjacent neurons, but also actively modulate neuronal transmission by releasing “glial transmitters,” such asExpand
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Differential Roles of NR2A- and NR2B-Containing NMDA Receptors in Activity-Dependent Brain-Derived Neurotrophic Factor Gene Regulation and Limbic Epileptogenesis
  • Qian Chen, Songtao He, +7 authors Z. Xiong
  • Biology, Medicine
  • The Journal of Neuroscience
  • 17 January 2007
Fleeting activation of NMDA receptors (NMDARs) induces long-term modification of synaptic connections and refinement of neuronal circuits, which may underlie learning and memory and contribute toExpand
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Spoligotyping and Drug Resistance Analysis of Mycobacterium tuberculosis Strains from National Survey in China
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis complex (MTBC), is one of the major causes of death in the world today. Although China has the second largest global case rate ofExpand
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  • Open Access
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains
BackgroundFrancisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover theExpand
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NF-kappaB and its regulation on the immune system.
NF-kappaB is a transcription factor of eukaryote, whose family comprises five members in mammals and three in drosophila. Transcription factors of the NF-kappaB family are activated in response toExpand
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Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC.
Exocytosis proceeds by either full fusion or 'kiss-and-run' between vesicle and plasma membrane. Switching between these two modes permits the cell to regulate the kinetics and amount of secretion.Expand
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Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study
BackgroundTuberculosis (TB) patients have difficulty following a long-term treatment regimen. Efforts to improve treatment outcomes require better understanding of adherence as a complex behavioralExpand
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Vitamin C enhances in vitro and in vivo development of porcine somatic cell nuclear transfer embryos.
The reprogramming of differentiated cells into a totipotent embryonic state through somatic cell nuclear transfer (SCNT) is still an inefficient process. Previous studies revealed that the generationExpand
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