• Publications
  • Influence
Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice
  • Q. He, Jun Pu, +6 authors B. He
  • Medicine
  • Cardiovascular Diabetology
  • 22 November 2014
BackgroundLiver X receptor (LXR) plays a critical regulatory role in metabolism and inflammation, and has been demonstrated to be involved in cardiovascular physiology/pathology. In the presentExpand
  • 33
  • 3
The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury
Circadian rhythm disruption or decrease in levels of circadian hormones such as melatonin increases ischemic heart disease risk. The nuclear melatonin receptors RORs are pivotally involved inExpand
  • 78
  • 2
DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli
Type VI secretion systems (T6SSs) contribute to pathogenicity in many pathogenic bacteria. Three distinguishable T6SS loci have been discovered in avian pathogenic Escherichia coli (APEC). TheExpand
  • 19
  • 2
  • Open Access
Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy.
AIMS To determine the roles of vitamin D receptor (VDR) in ischemia/reperfusion-induced myocardial injury and to investigate the underlying mechanisms involved. RESULTS The endogenous VDRExpand
  • 88
  • 1
  • Open Access
Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy
Although pathological cardiac hypertrophy represents a leading cause of morbidity and mortality worldwide, our understanding of the molecular mechanisms underlying this disease is still poor. Here,Expand
  • 37
  • 1
YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating
Positive evidence from clinical trials has fueled growing acceptance of traditional Chinese medicine (TCM) for the treatment of cardiac diseases; however, little is known about the underlyingExpand
  • 34
  • 1
The desumoylating enzyme sentrin-specific protease 3 contributes to myocardial ischemia reperfusion injury.
  • L. Gao, Y. Zhao, +11 authors J. Pu
  • Medicine, Biology
  • Journal of genetics and genomics = Yi chuan xue…
  • 1 December 2017
Sentrin-specific protease 3 (SENP3), a member of the desumoylating enzyme family, is known as a redox sensor and could regulate multiple cellular signaling pathways. However, its implication inExpand
  • 8
  • 1
Novel Protective Role for Ubiquitin-Specific Protease 18 in Pathological Cardiac Remodeling
Ubiquitin-specific protease 18 (USP18), a USP family member, is involved in antiviral activity and cancer inhibition. Although USP18 is expressed in heart, the role of USP18 in the heart and inExpand
  • 10
  • 1
IbeR Facilitates Stress-Resistance, Invasion and Pathogenicity of Avian Pathogenic Escherichia coli
Systemic infections by avian pathogenic Escherichia coli (APEC) are economically devastating to poultry industries worldwide. IbeR, located on genomic island GimA, was shown to serve as an RpoS-likeExpand
  • 6
  • 1
Novel protective role of the circadian nuclear receptor retinoic acid‐related orphan receptor‐α in diabetic cardiomyopathy
Diabetic cardiomyopathy is a major complication that significantly contributes to morbidity and mortality in diabetics with few therapies. Moreover, antidiabetic drugs reported inconsistent or evenExpand
  • 22