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The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress response.
An essential part of the cellular response to environmental stress is a reversible translational suppression, taking place in dynamic cytoplasmic structures called stress granules (SGs). We… Expand
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
- Q. Sun, X. Chen, +17 authors H. Zhang
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 15 February 2011
Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear. For a largely unknown… Expand
Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming.
DNA methylation and demethylation have been proposed to play an important role in somatic cell reprogramming. Here, we demonstrate that the DNA hydroxylase Tet1 facilitates pluripotent stem cell… Expand
Zebrafish Dpr2 Inhibits Mesoderm Induction by Promoting Degradation of Nodal Receptors
Nodal proteins, members of the transforming growth factor–β (TGFβ) superfamily, have been identified as key endogenous mesoderm inducers in vertebrates. Precise control of Nodal signaling is… Expand
SOX4 induces epithelial-mesenchymal transition and contributes to breast cancer progression.
Epithelial-mesenchymal transition (EMT) is a developmental program, which is associated with breast cancer progression and metastasis. Here, we report that ectopic overexpression of SOX4 in… Expand
Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance.
Gain of chromosome 11q13 is a common event in esophageal squamous cell carcinoma (ESCC). The cortactin gene (CTTN, also EMS1), located at 11q13, plays a pivotal role in coupling membrane dynamics to… Expand
iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.
Summary To our knowledge, for the first time, we demonstrate that induced pluripotent stem cells (iPSCs) can autonomously generate full-term mice via tetraploid blastocysts complementation.… Expand
Histone deacetylases 1 and 2 act in concert to promote the G1-to-S progression.
- T. Yamaguchi, Fabien Cubizolles, +4 authors P. Matthias
- Biology, Medicine
- Genes & development
- 1 March 2010
Histone deacetylases (HDACs) regulate gene expression by deacetylating histones and also modulate the acetylation of a number of nonhistone proteins, thus impinging on various cellular processes.… Expand
MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a
MicroRNAs are ∼21nt single-stranded RNAs and function as regulators of gene expression. Previous studies have shown that microRNAs play crucial roles in tumorigenesis by targeting the mRNAs of… Expand
RNA-Seq reveals expression signatures of genes involved in oxygen transport, protein synthesis, folding, and degradation in response to heat stress in catfish.
Temperature is one of the most prominent abiotic factors affecting ectotherms. Most fish species, as ectotherms, have extraordinary ability to deal with a wide range of temperature changes. While the… Expand