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Evolution of genes and genomes on the Drosophila phylogeny
TLDR
These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Expand
In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
TLDR
Global comparison of several structural features between these two categories shows that the mRNAs associated with stress responses tend to have more single-strandedness, longer maximal loop length and higher free energy per nucleotide, features that may allow these RNAs to undergo conformational changes in response to environmental conditions. Expand
Sparse whole genome sequencing identifies two loci for major depressive disorder
TLDR
Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene. Expand
Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
TLDR
It is shown that MRX recruits Dna2 nuclease to D SB ends and stimulates recruitment of Exo1 and antagonizes excess binding of the Ku complex to DSB ends, which provide new insights into how MRX catalyses end resection and recombination initiation. Expand
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
TLDR
A panoramic view of the landscape of H3K4me3, a histone hallmark for transcription initiation, from developing gametes to post-implantation embryos is provided by developing a highly sensitive approach, STAR ChIP–seq, to unveil inheritance and highly dynamic reprogramming of the epigenome in early mammalian development. Expand
Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy
TLDR
Patients with an autoimmune disorder caused by deficiency of a protein called LRBA responded dramatically to the drug abatacept, a CTLA4 (cytotoxic T lymphocyte antigen-4)–immunoglobulin fusion drug, and the relationship between the two proteins was revealed: LRBA controls the intracellular trafficking and degradation ofCTLA4. Expand
Sequence and analysis of rice chromosome 4
TLDR
Comparative genome analysis between cultivated rice subspecies shows that there is an overall syntenic relationship between the chromosomes and divergence at the level of single-nucleotide polymorphisms and insertions and deletions, and by contrast, there is little conservation in gene order between rice and Arabidopsis. Expand
Arabidopsis CULLIN4-Damaged DNA Binding Protein 1 Interacts with CONSTITUTIVELY PHOTOMORPHOGENIC1-SUPPRESSOR OF PHYA Complexes to Regulate Photomorphogenesis and Flowering Time[C][W]
TLDR
It is demonstrated that CUL4-DDB1 physically associates with COP1-SPA complexes in vitro and in vivo, likely via direct interaction of DDB1 with COP 1 and SPAs, and may mediate the repression of photomorphogenesis and, possibly, of flowering time. Expand
Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia
TLDR
Camels serve as an important reservoir for the maintenance and diversification of the MERS-CoVs and are the source of human infections with this virus, according to surveillance in Saudi Arabia in 2014 and 2015. Expand
Simultaneous determination of multi-component mycotoxin contaminants in foods and feeds by ultra-performance liquid chromatography tandem mass spectrometry.
TLDR
An improved analytical method for the simultaneous quantification of 17 kinds of Aspergillus, Fusarium and Penicillium mycotoxin contaminants in foods and feeds by ultra-performance liquid chromatography combined with electrospray ionization triple quadrupole tandem mass spectrometry under the multiple reaction monitoring (MRM) mode. Expand
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