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FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation… Expand
Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer
The evolution of prostate cancer from an androgen-dependent state to one that is androgen-independent marks its lethal progression. The androgen receptor (AR) is essential in both, though its… Expand
A Mammalian Organelle Map by Protein Correlation Profiling
Protein localization to membrane-enclosed organelles is a central feature of cellular organization. Using protein correlation profiling, we have mapped 1,404 proteins to ten subcellular locations in… Expand
SOAPnuke: a MapReduce acceleration-supported software for integrated quality control and preprocessing of high-throughput sequencing data
We demonstrate SOAPnuke as a workflow-like tool with abundant functions for a “QC-Preprocess-QC” workflow and MapReduce acceleration framework. Expand
Mutagenesis of phospholipase D defines a superfamily including a trans‐Golgi viral protein required for poxvirus pathogenicity
Phospholipase D (PLD) genes are members of a superfamily that is defined by several highly conserved motifs. PLD in mammals has been proposed to play a role in membrane vesicular trafficking and… Expand
Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them.
Fragile X syndrome, the most common form of hereditary mental retardation, usually results from lack of expression of the FMR1 gene. The FMR1 protein is a cytoplasmic RNA-binding protein. The… Expand
Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway
Individuals with gallbladder carcinoma (GBC), the most aggressive malignancy of the biliary tract, have a poor prognosis. Here we report the identification of somatic mutations for GBC in 57… Expand
Molecular cloning, characterization and expression profiles of multiple leptin genes and a leptin receptor gene in orange-spotted grouper (Epinephelus coioides).
- H. Zhang, Huapu Chen, +6 authors H. Lin
- Biology, Medicine
- General and comparative endocrinology
- 15 January 2013
Leptin plays key roles in body weight regulation, energy metabolism, food intake, reproduction and immunity in mammals. However, its function in teleosts is still unclear. In the present study, two… Expand
Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice
Zika virus (ZIKV) persists in the semen of male patients, a first for flavivirus infection. Here, we demonstrate that ZIKV can induce inflammation in the testis and epididymidis, but not in the… Expand
MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
- Xiaobin Luo, Zhenwei Pan, +20 authors S. Nattel
- Biology, Medicine
- The Journal of clinical investigation
- 1 May 2013
Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Inward-rectifier K+ current (IK1) is believed to be an important regulator of reentrant-spiral… Expand