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The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fattyExpand
Regulation of Lipoprotein Lipase by the Oxysterol Receptors, LXRα and LXRβ*
Lipoprotein lipase (LPL) is a key enzyme for lipoprotein metabolism and is responsible for hydrolysis of triglycerides in circulating lipoproteins, releasing free fatty acids to peripheral tissues.Expand
Exosomal miR-221/222 enhances tamoxifen resistance in recipient ER-positive breast cancer cells
Recent studies have demonstrated that specific miRNAs, such as miR-221/222, may be responsible for tamoxifen resistance in breast cancer. Secreted miRNAs enclosed in exosomes can act as intercellularExpand
Denervation-induced mitochondrial dysfunction and autophagy in skeletal muscle of apoptosis-deficient animals.
Skeletal muscle undergoes remarkable adaptations in response to chronic decreases in contractile activity, such as a loss of muscle mass, decreases in both mitochondrial content and function, as wellExpand
CysLT 1 R Antagonists Inhibit Tumor Growth in a Xenograft Model of Colon Cancer
The expression of the inflammatory G-protein coupled receptor CysLT1R has been shown to be upregulated in colon cancer patients and associated with poor prognosis. The present study investigated theExpand
The Cysteine-Cysteine Family of Chemokines RANTES, MIP-1α, and MIP-1β Induce Trypanocidal Activity in Human Macrophages via Nitric Oxide
ABSTRACT This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1α, and MIP-1β on human macrophage function, which is the induction of nitric oxide (NO)-mediatedExpand
The Pseudogene Olfr29-ps1 Promotes the Suppressive Function and Differentiation of Monocytic MDSCs
A conserved long noncoding RNA (lncRNA), pseudogene Olfr29-ps1, was identified and shown to be induced under inflammatory conditions and in melanomas. Olfr29-ps1 can regulate the immunosuppressiveExpand
High glucose induces macrophage inflammatory protein-3α in renal proximal tubule cells via a transforming growth factor-β1 dependent mechanism
Background. Hyperglycaemia is a causative factor in the pathogenesis of diabetic nephropathy, known to induce chemokines in the kidney. Macrophage inflammatory protein-3a (MIP-3a) is a CC chemokineExpand
Adenosine Monophosphate Activated Protein Kinase Regulates ABCG1-Mediated Oxysterol Efflux From Endothelial Cells and Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction
Objective—Adenosine monophosphate activated protein kinase (AMPK) has been identified as a regulator of vascular function via the preservation of endothelial cell (EC) function. In this study, weExpand
Overview of orchestration of CD4+ T cell subsets in immune responses.
  • B. Sun, Y. Zhang
  • Biology, Medicine
  • Advances in experimental medicine and biology
  • 2014
Adaptive immunity plays an important role in the host defense of pathogens, among which CD4+ T helper cell takes a major part. The regulation of Th cell differentiation, the function they exerts inExpand