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Structure of the RNA-dependent RNA polymerase from COVID-19 virus
The COVID-19 RNA-synthesizing machine Many in the scientific community have mobilized to understand the virus that is causing the global coronavirus disease 2019 (COVID-19) pandemic. Gao et al.Expand
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.
Recent discoveries of histone demethylases demonstrate that histone methylation is reversible. However, mechanisms governing the targeting and regulation of histone demethylation remain elusive. HereExpand
Functional characterisation of the recombinant tumor necrosis factors in rainbow trout, Oncorhynchus mykiss.
Tumor necrosis factor (TNF) is a key mediator in regulating the inflammatory response. Previously two TNF genes have been cloned and sequenced from rainbow trout, Oncorhynchus mykiss. In this study,Expand
Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.
The majority of preproteins destined for mitochondria carry N-terminal presequences. The presequence translocase of the inner mitochondrial membrane (TIM23 complex) plays a central role in proteinExpand
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotency.
N(6)-methyladenosine (m(6)A) has been recently identified as a conserved epitranscriptomic modification of eukaryotic mRNAs, but its features, regulatory mechanisms, and functions in cellExpand
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome
The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome
Global analysis of metabolites in rat and human urine based on gas chromatography/time-of-flight mass spectrometry.
Sediment in urine may contain low-molecular-weight compounds that should be included in the analysis. To date, no systematic investigation has addressed this issue. We investigated three primaryExpand
Genotype shift in human coronavirus OC43 and emergence of a novel genotype by natural recombination
Summary Background Human coronavirus (HCoV) OC43 is the most prevalent HCoV in respiratory tract infections. Its molecularExpand
Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation
Summary How cells adapt metabolism to meet demands is an active area of interest across biology. Among a broad range of functions, the polyamine spermidine is needed to hypusinate the translationExpand
Architecture of a SARS-CoV-2 mini replication and transcription complex
Non-structural proteins (nsp) constitute the SARS-CoV-2 replication and transcription complex (RTC) to play a pivotal role in the virus life cycle. Here we determine the atomic structure of aExpand