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Constraint and turnover in sex-biased gene expression in the genus Drosophila
Both genome content and deployment contribute to phenotypic differences between species. Sex is the most important difference between individuals in a species and has long been posited to be rapidly… Expand
Demasculinization of X chromosomes in the Drosophila genus
X chromosomes evolve differently from autosomes, but general governing principles have not emerged. For example, genes with male-biased expression are under-represented on the X chromosome of D.… Expand
Synthetic spike-in standards for RNA-seq experiments.
High-throughput sequencing of cDNA (RNA-seq) is a widely deployed transcriptome profiling and annotation technique, but questions about the performance of different protocols and platforms remain. We… Expand
Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA expression.
The transcription factor GATA1 regulates an extensive program of gene activation and repression during erythroid development. However, the associated mechanisms, including the contributions of distal… Expand
Complete Khoisan and Bantu genomes from southern Africa
The genetic structure of the indigenous hunter-gatherer peoples of southern Africa, the oldest known lineage of modern human, is important for understanding human diversity. Studies based on… Expand
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
Interplays among lineage-specific nuclear proteins, chromatin modifying enzymes, and the basal transcription machinery govern cellular differentiation, but their dynamics of action and coordination… Expand
Linkage map for Aedes aegypti using restriction fragment length polymorphisms.
We report construction of a genetic linkage map for the mosquito, Aedes aegypti, based on restriction fragment length polymorphisms (RFLPs). The map consists of 50 DNA markers that identify 53 loci… Expand
The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7.
The recently identified mouse obese (ob) gene apparently encodes a secreted protein that may function in the signaling pathway of adipose tissue. Mutations in the mouse ob gene are associated with… Expand
Specification of neuroblast identity in the Drosophila embryonic central nervous system by gooseberry-distal
THE Drosophila central nervous system develops from a segment-ally reiterated array of 30 unique neural precursors, called neuro-blasts. Each neuroblast goes through a stereotyped cell lineage to… Expand
A complete sequence and comparative analysis of a SARS-associated virus (Isolate BJ01)
- E. Qin, Qingyu Zhu, +44 authors H. Yang
- Biology, Medicine
- Chinese science bulletin = Kexue tongbao
The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution,… Expand