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Abnormal Spine Morphology and Enhanced LTP in LIMK-1 Knockout Mice
In vitro studies indicate a role for the LIM kinase family in the regulation of cofilin phosphorylation and actin dynamics. In addition, abnormal expression of LIMK-1 is associated with Williams… Expand
COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability.
Seasonal changes in day length are perceived by plant photoreceptors and transmitted to the circadian clock to modulate developmental responses such as flowering time. Blue-light-sensing… Expand
LSD1 Is a Subunit of the NuRD Complex and Targets the Metastasis Programs in Breast Cancer
Lysine-specific demethylase 1 (LSD1) exerts pathway-specific activity in animal development and has been linked to several high-risk cancers. Here, we report that LSD1 is an integral component of the… Expand
Spatial Organization of the Mouse Genome and Its Role in Recurrent Chromosomal Translocations
The extent to which the three-dimensional organization of the genome contributes to chromosomal translocations is an important question in cancer genomics. We generated a high-resolution Hi-C spatial… Expand
An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway
Chromosomal translocations arise from the misjoining of DNA breaks, but the identity of the DNA repair factors and activities involved in their formation has been elusive. Here we show that depletion… Expand
Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins.
- Rohit Prakash, Y. Zhang, Weiran Feng, M. Jasin
- Biology, Medicine
- Cold Spring Harbor perspectives in biology
- 1 April 2015
Homologous recombination (HR) is a major pathway for the repair of DNA double-strand breaks in mammalian cells, the defining step of which is homologous strand exchange directed by the RAD51 protein.… Expand
Synaptic Transmission and Plasticity in the Absence of AMPA Glutamate Receptor GluR2 and GluR3
The AMPA glutamate receptor (AMPAR) subunits GluR2 and GluR3 are thought to be important for synaptic targeting/stabilization of AMPARs and the expression of hippocampal long-term depression (LTD).… Expand
Genome-wide Translocation Sequencing Reveals Mechanisms of Chromosome Breaks and Rearrangements in B Cells
Whereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote them are poorly understood. To elucidate translocation mechanisms in mammalian cells, we developed… Expand
Stimulation of in vitro anaerobic oxidation of methane rate in a continuous high-pressure bioreactor.
- Y. Zhang, Jean-Pierre Henriet, J. Bursens, N. Boon
- Medicine, Chemistry
- Bioresource technology
- 1 May 2010
Anaerobic oxidation of methane coupled to sulphate reduction (SR-AOM) prevents oceanic methane emissions and is considered as a major environmental process in the deep-sea sediments. To stimulate in… Expand
Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System
Chromosomal translocations involving antigen receptor loci are common in lymphoid malignancies. Translocations require DNA double-strand breaks (DSBs) at two chromosomal sites, their physical… Expand