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A distinct mechanism regulating a pollen-specific guanine nucleotide exchange factor for the small GTPase Rop in Arabidopsis thaliana
  • Y. Zhang, S. McCormick
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 20 November 2007
TLDR
The results suggest a mechanism by which the noncatalytic domains of pollen-specific/enriched RopGEFs regulate PRONE function, leading to polarized pollen tube growth. Expand
Isolation and partial characterization of pepsin-soluble collagen from the skin of grass carp (Ctenopharyngodon idella)
TLDR
Pepsin-soluble collagen was extracted from the skin of grass carp with a yield of 46.6%, suggesting that grass carp skin has potential for use as a supplementary source of collagen. Expand
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients
TLDR
Results show that sunitinib targets the autoinhibited conformation of WT KIT and that the D816H mutant undergoes a shift in conformational equilibrium toward the active state, providing a structural and enzymologic explanation for the resistance profile observed with the KIT inhibitors. Expand
Targeted disruption of hsf1 leads to lack of thermotolerance and defines tissue‐specific regulation for stress‐inducible Hsp molecular chaperones
TLDR
It is demonstrated that Hsf1 is critical for maintaining cellular integrity after heat stress and that cells from hsf1−/− mice lack the ability to develop thermotolerance. Expand
Characterization of novel natural killer (NK)-cell and gammadelta T-cell lines established from primary lesions of nasal T/NK-cell lymphomas associated with the Epstein-Barr virus.
TLDR
This is the first report of the establishment of cell lines from primary lesions of nasal T/NK cell lymphomas, and the results demonstrated that there are at least 2 lineages, NK- and gammadelta T-cell, in this neoplasm. Expand
An overview of characteristics of municipal solid waste fuel in China: Physical, chemical composition and heating value
In this paper, the characteristics of physical and chemical composition of municipal solid waste (MSW) in China were reviewed and the statistical indexes, namely mean value, standard deviation,Expand
SPL8, a local regulator in a subset of gibberellin-mediated developmental processes in Arabidopsis
TLDR
This study uncovered a tissue-dependent regulatory role for SPL8 in the response to GA signalling in plant development, and determined that constitutive overexpression of SPL8 affects fertility due to non-dehiscent anthers, likely resulting from a constitutive GA response. Expand
Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics
TLDR
It is suggested that anthropogenic activities resulting in elevated levels of turbidity, organic matter, and metals have opened a niche within coastal ecosystems that ideally suits the unique genetic capacity of A. anophagefferens and thus, has facilitated the proliferation of this and potentially other HABs. Expand
Structural basis for recruitment of mitochondrial fission complexes by Fis1
  • Y. Zhang, D. Chan
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 20 November 2007
TLDR
Genetic and biochemical studies indicate that both binding interfaces are important for binding of Mdv1 and Caf4 to Fis1 and for mitochondrial fission activity in vivo, and crystallographic analysis of adaptor-Fis1 complexes shows that these adaptors use two helices to bind to both the concave and convex surfaces of the Fis2 TPR domain. Expand
New insights into mitochondrial fusion
TLDR
This work highlights recent findings that have advanced the understanding of the mechanism, function, and regulation of mitochondrial fusion, and identifies key components of the mitochondrial fusion machinery that likely mediate outer membrane fusion. Expand
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