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JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
This work identifies a histone demethylase and links its function to hormone-dependent transcriptional activation, resulting in H3K9 demethylation and transcriptionalactivation. Expand
hDOT1L Links Histone Methylation to Leukemogenesis
It is reported that hDOT1L interacts with AF10, an MLL (mixed lineage leukemia) fusion partner involved in acute myeloid leukemia, through the OM-LZ region of AF10 required for MLL-AF10-mediated leukemogenesis, and suggests that the enzymatic activity of hDot1L may provide a potential target for therapeutic intervention. Expand
Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells.
It is suggested for the first time that human MSCs could suppress monocyte differentiation into DCs, the most potent antigen-presenting cells (APCs), thus indicating the versatile regulation of M SCs on the ultimate specific immune response. Expand
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
It is found that the phosphorylation response to insulin is largely mTOR dependent and that mTOR exhibits a unique preference for proline, hydrophobic, and aromatic residues at the +1 position. Expand
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells.
This study reveals the first genome-wide 5hmC distribution in pluripotent stem cells, and supports its dual function in regulating gene expression. Expand
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
The mechanism and function of DNA demethylation in mammalian genomes is discussed, focusing particularly on how developmental modulation of the cytosine-modifying pathway is coupled to active reversal of DNA methylation in diverse biological processes. Expand
Embryonic Development following Somatic Cell Nuclear Transfer Impeded by Persisting Histone Methylation
H3K9me3 of donor cell genome is identified as a critical epigenetic barrier in SCNT-mediated reprogramming and provides a promising approach for improving mammalian cloning efficiency. Expand
Subtypes of breast cancer show preferential site of relapse.
The five major molecular subtypes in breast cancer are evidently different with regard to their ability to metastasize to distant organ(s), and share biological features and pathways with their preferred distant metastatic site. Expand
Auxin binding protein 1 (ABP1) is not required for either auxin signaling or Arabidopsis development
- Y. Gao, Y. Zhang, Da Zhang, Xinhua Dai, M. Estelle, Yunde Zhao
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2 February 2015
It is concluded that ABP1 is not a key component in auxin signaling or Arabidopsis development, and the induction of known auxin-regulated genes is similar in both wild-type and abp1 plants in response to auxin treatments. Expand
Tumor-associated macrophages: from basic research to clinical application
The origin, polarization, and role of TAMs in human malignant tumors, as well as how TAMs can be used as diagnostic and prognostic biomarkers and therapeutic targets of cancer in clinics are discussed. Expand