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Role of herpes simplex virus type 1 UL46 and UL47 in alpha TIF-mediated transcriptional induction: characterization of three viral deletion mutants.
It is demonstrated that neither UL46- nor UL47-encoded gene product, either separately or in combination, is required for viral growth in cell culture, and Western immunoblot analysis demonstrated that the accumulation and steady-state levels ofalpha TIF or alpha TIF-containing proteins was indistinguishable from that of the thymidine kinase-negative isogenic parental virus, R delta 305. Expand
Selective activity of various antiviral compounds against HHV-7 infection.
In general, PS, DS, PVAS, PAVAS, ATA, PFA, PMEA, S2242, lobucavir and HPMPC had comparable anti-HHV-7 activity in the two cell lines, irrespective of the parameters followed to monitor antiviral activity. Expand
Severe Murine Lung Immunopathology Elicited by the Pathogenic Equine Herpesvirus 1 Strain RacL11 Correlates with Early Production of Macrophage Inflammatory Proteins 1α, 1β, and 2 and Tumor Necrosis…
- P. Smith, Y. Zhang, W. Grafton, S. Jennings, D. O’Callaghan
- Biology, Medicine
- Journal of Virology
- 1 November 2000
It is suggested that the early production of proinflammatory beta chemokines plays a major role in the severe, most often lethal, respiratory inflammatory response induced by the pathogenic EHV-1 strain RacL11. Expand
Productive Infection of Primary Macrophages with Human Herpesvirus 7
- Y. Zhang, L. De Bolle, S. Aquaro, A. van Lommel, E. De Clercq, D. Schols
- Medicine, Biology
- Journal of Virology
- 1 November 2001
ABSTRACT Here we demonstrate replication of human herpesvirus 7 (HHV-7), a T-lymphotropic virus, in macrophages. Productive replication was lost after 2 weeks, but HHV-7 DNA was detected up to 1… Expand
CXC-Chemokine Receptor 4 Is Not a Coreceptor for Human Herpesvirus 7 Entry into CD4+ T Cells
The results presented here demonstrate that CXCR4 is not involved in HHV-7 infection, and two different agents known to specifically interact with CX CR4 were not able to inhibit HHV -7 infection. Expand
Attention on patent foramen ovale and its related paroxysmal neurological diseases