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Interleukin-1 can inhibit interferon-beta synthesis and its antiviral action: comparison with tumor necrosis factor.
Earlier studies showed that both tumor necrosis factor (TNF) and interleukin-1 (IL1) can inhibit virus replication in cultured cells. However, in human FS-4 fibroblasts, in which recombinant humanExpand
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Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes.
Cellular and molecular mechanisms of the immunomodulatory action of glycyrrhizin (GL) were studied. We demonstrated that GL displays a unique action to prolong the duration of the T-cellExpand
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Immunochemical and functional analysis of Ia-like antigens on human monocyte-macrophages with monoclonal antibodies.
Abstract The distribution, structural profile and functional properties of Ia-like antigens synthesized by human monocyte-macrophages have been analyzed using monoclonal antibodies to commonExpand
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Characterization of the immunoregulatory action of saikosaponin-d.
The immunoregulatory action of saikosaponin-d (SSd), which was isolated from the root of Bupleurum falcatum L. and has a steroid-like structure, was examined on splenic T lymphocytes of C57BL/6 mice.Expand
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Effects of pretreatment with protein kinase C activators on macrophage activation for tumor cytotoxicity, secretion of tumor necrosis factor, and its mRNA expression.
The effect of phorbol esters and mezerein pretreatment on macrophage (M phi) activation for tumor cytolysis, tumor necrosis factor (TNF) secretion, and TNF-alpha mRNA expression was investigated.Expand
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Pathway of signal delivery to murine thymocytes triggered by co-crosslinking CD3 and Thy-1 for cellular DNA fragmentation and growth inhibition.
The signal delivery pathway triggered by crosslinking CD3 and Thy-1 together (CD3/Thy-1 crosslinkage) on murine thymocytes for cellular DNA fragmentation/growth inhibition was analyzed. The treatmentExpand
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Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations.
Glycyrrhizin (GL), a saponin fraction of licorice with defined chemical structure, was shown to display a definite action in vitro augmenting the cell-surface expression of H-2 class I antigens asExpand
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Allotype-linked immune response genes: roles in network control of the immune system.
Studies on allotype-linked immune response genes and related genes are overviewed with particular attention to our current results in unique models. Significance of actions of various immune responseExpand
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Bidirectional control by glycyrrhizin of the growth response of lymphocytes stimulated through a receptor-bypassed pathway.
This study demonstrates a unique action of glycyrrhizin (GL) in bidirectionally controlling the growth response of lymphocytes stimulated through a receptor-bypassed pathway by calcium ionophoreExpand
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