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Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis.
TLDR
Findings suggest a novel pathophysiologic concept wherein the acute host response to Chlamydia at mucosal surfaces is primarily initiated and sustained by epithelial cells, the first and major targets of chlamydial infection.
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Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes.
TLDR
An arrangement of MOMP in the outer membrane in which three of the four variable domains are exposed to the outside and in which both N and C termini are presumably oriented toward the periplasmic space is suggested.
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Nucleotide and deduced amino acid sequences for the four variable domains of the major outer membrane proteins of the 15 Chlamydia trachomatis serovars
TLDR
The MOMP VDs of given serovars with the greatest total hydrophilicity and charge values were found to be the location of antigenic determinants recognized by MomP-specific monoclonal antibodies, which should be useful for predicting MOMPs antigeniceterminants and testing the antigenic properties of these VDs by using synthetic peptides corresponding to each MOMp VD.
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Chlamydia trachomatis-host cell interactions: role of the chlamydial major outer membrane protein as an adhesin
TLDR
It is proposed that the MOMP functions as a chlamydial adhesin by promoting nonspecific (electrostatic and hydrophobic) interactions with host cells and contributes to the binding of chlamydiae to host cells.
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Protective efficacy of major outer membrane protein-specific immunoglobulin A (IgA) and IgG monoclonal antibodies in a murine model of Chlamydia trachomatis genital tract infection
TLDR
It is indicated that the presence of IgA or IgG MAbs specific to major outer membrane proteins has a marginal effect in preventing chlamydial colonization and shedding from the genital tract but has a more pronounced effect on ascending chlamYDial infection and accompanying upper genital tract pathology.
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Protective monoclonal antibodies recognize epitopes located on the major outer membrane protein of Chlamydia trachomatis.
TLDR
Data suggest that those major outer membrane protein antigenic determinants that are serovar or serogroup specific and are accessible to antibody on the chlamydial cell surface may be useful as a recombinant subunit vaccine for trachoma.
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Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains
TLDR
The cloned and sequenced the gene encoding the major outer membrane protein (MOMP) of two Chlamydia psittaci strains, guinea pig inclusion conjunctivitis (GPIC) strain 1, and meningopneumonitis (Mn) strain Cal-10 indicate that C. trachomatis and C. Psittaci diverged from a common ancestor.
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Monoclonal antibodies define genus-specific, species-specific, and cross-reactive epitopes of the chlamydial 60-kilodalton heat shock protein (hsp60): specific immunodetection and purification of…
TLDR
The antichlamydial hsp60 monoclonal antibodies (MAbs) described here should be extremely useful for the specific immunodetection of hSp60 in tissues from individuals having different disease manifestations and for the purification of h Sp60 or truncated hsp 60 polypeptides for use in serologic and lymphocyte proliferation assays.
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Regulation of Vibrio alginolyticus virulence by the LuxS quorum-sensing system.
TLDR
The results suggest that the LuxS QS system plays an important role in regulating the expression of virulence factors in V. alginolyticus.
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In vitro activity of sparfloxacin
TLDR
Sparfloxacin, a new fluoroquinolone, inhibited the majority of members of the family Enterobacteriaceae at less than or equal to 1 microgram/ml and against Pseudomonas aeruginosa, it was less active than ciprofl oxacin but twofold more active than ofloxacIn.
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