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Selective cytotoxicity of intracellular amyloid β peptide1–42 through p53 and Bax in cultured primary human neurons
TLDR
The data directly demonstrate that intracellular Aβ1–42 is selectively cytotoxic to human neurons through the p53–Bax cell death pathway.
Reactive oxygen species in cancer stem cells.
TLDR
This work has shown that normal stem cells such as hematopoietic stem cells reside in niches characterized by hypoxia and low ROS, both of which are critical for maintaining the potential for self-renewal and stemness, and the roles of ROS in CSCs remain poorly understood.
Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits
TLDR
Using the retrograde, transsynaptic tracer pseudorabies virus (PRV) injected into the BAT of mice, PRV-labeled LepRb neurons in the DMH/DHA and mPOA (and other sites) are identified, indicating their involvement in the regulation of sympathetic BAT circuits.
miR-125b is methylated and functions as a tumor suppressor by regulating the ETS1 proto-oncogene in human invasive breast cancer.
TLDR
It is reported that miR-125b is downregulated in invasive breast cancers where it predicts poor patient survival and is suggested as a potential theranostic tool in this disease.
Positive and negative regulation of granulocyte-macrophage colony-stimulating factor promoter activity by AML1-related transcription factor, PEBP2.
TLDR
The present findings suggested the importance of the relative ratio of different PEBP2 isoforms in regulating the levels of the promoter activity in granulocyte-macrophage colony-stimulating factors.
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients
TLDR
Whether the expression of PD-1 and PD-L1 is upregulated in septic shock patients is determined and the role of this pathway in sepsis-induced immunosuppression is explored to explore.
The Rett Syndrome Protein MeCP2 Regulates Synaptic Scaling
TLDR
Observations indicate that MeCP2 mediates activity-dependent synaptic scaling, and suggest that the pathophysiology of Rett syndrome, which is caused by mutations in Me CP2, may involve defects in activity- dependent regulation of synaptic currents.
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction
TLDR
Anti-PD-L1 antibody administration prevented sepsis-induced depletion of lymphocytes, increased tumor necrosis factor (TNF)-α and interleukin (IL)-6 production, decreased IL-10 production, and enhanced bacterial clearance and exerts a protective effect on sepsi at least partly by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction.
Side population in oral squamous cell carcinoma possesses tumor stem cell phenotypes.
TLDR
Findings provide the first evidence that SP in OCC possesses tumor stem cell phenotypes and may play an important role in O CC tumorigenesis.
Trachea-derived dpp controls adult midgut homeostasis in Drosophila.
TLDR
It is demonstrated that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult midgut homeostasis and it is shown that Dpp signaling is primarily activated in enterocytes (ECs).
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