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Drivers shaping the diversity and biogeography of total and active bacterial communities in the South China Sea
To test the hypothesis that different drivers shape the diversity and biogeography of the total and active bacterial community, we examined the bacterial community composition along two transects,… Expand
Contribution of major bacterial groups to bacterial biomass production along a salinity gradient in the South China Sea
Bacterial abundance and assimilation of 3 H-leucine were examined using a combination of microautoradiography and fluorescent in situ hybridization (Micro-FISH) to determine the bacterioplankton… Expand
Predicting Long Noncoding RNA and Protein Interactions Using Heterogeneous Network Model
- A. Li, Mengqu Ge, Y. Zhang, C. Peng, M. Wang
- Computer Science, Medicine
- BioMed research international
- 29 December 2015
In this paper, we introduce a network-based method, lncRNA-protein interaction prediction based on Heterogeneous Network Model (LPIHN), to predict the interactions between lncRNAs and proteins. Expand
Dynamics of aerobic anoxygenic phototrophic bacteria in the East China Sea.
Aerobic anoxygenic phototrophic bacteria (AAPB) are a group of heterotrophic bacteria capable of photosynthesis. The dynamics of AAPB in the East China Sea, a typical marginal sea characterized by… Expand
The effectiveness of wikis for project-based learning in different disciplines in higher education
We compared the perceptions and actions among students in three undergraduate courses of different disciplines, English Language Studies, Information Management, and Mechanical Engineering, who used wikis in their course assignments. Expand
Diversity and distribution of diazotrophic communities in the South China Sea deep basin with mesoscale cyclonic eddy perturbations.
The South China Sea (SCS) is an oligotrophic subtropical marginal ocean with a deep basin and a permanently stratified central gyre. Upwelling and nitrogen fixation provide new nitrogen for primary… Expand
Hyperphosphorylation of microtubule-associated tau protein plays dual role in neurodegeneration and neuroprotection.
- Y. Zhang, Q. Tian, Q. Zhang, Xinwen Zhou, S. Liu, J. Wang
- Biology, Medicine
- Pathophysiology : the official journal of the…
- 1 October 2009
The microtubule-associated protein tau plays a major role in maintaining the normal morphology of the neurons. The major biological activity of tau is to promote microtubule assembly and stabilize… Expand
A hybrid mixture discriminant analysis-random forest computational model for the prediction of volume of distribution of drugs in human.
- F. Lombardo, R. Obach, +6 authors Y. Zhang
- Chemistry, Medicine
- Journal of medicinal chemistry
- 14 March 2006
A computational approach is described that can predict the VD(ss) of new compounds in humans, with an accuracy of within 2-fold of the actual value. A dataset of VD values for 384 drugs in humans was… Expand
Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins
Intracellular accumulation of tau protein is hallmark of sporadic Alzheimer’s disease (AD), however, the cellular mechanism whereby tau accumulation causes neurodegeneration is poorly understood.… Expand
Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1.
- Dan Wei, Rongya Tao, Y. Zhang, M. White, X. C. Dong
- Biology, Medicine
- American journal of physiology. Endocrinology and…
- 1 February 2011
Protein deacetylase Sirt1 has been implicated in the regulation of hepatic gluconeogenesis; however, the mechanisms are not fully understood. To further elucidate how Sirt1 regulates gluconeogenesis,… Expand