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Structural insight into the autoinhibition mechanism of AMP-activated protein kinase
The structural and biochemical data have shown the primary mechanism of AMPK autoinhibition and suggest a conformational switch model for AMPK activation by AMP. Expand
AMP-activated protein kinase undergoes nucleotide-dependent conformational changes
Mutagenesis studies indicate that sites 3 and 4 are important for AMPK allosteric activation. Expand
Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering
It is presented the first demonstration that increasing NADPH availability by overexpressing the pntAB or nadK genes significantly enhances SA production, and an E. coli strain that carries neither a plasmid nor an antibiotic marker was constructed by triclosan-induced chromosomal evolution. Expand
Genetic and QTL analysis for low-temperature vigor of germination in rice.
The quantitative trait loci (QTLs) for low-temperature vigor of germination (LVG) with a germination period of 7 d, 11 d, 14 d, and 17 d at 14 degrees C was identified using F(2:3) population, whichExpand
The role of Leptotrombidium scutellare in the transmission of human diseases.
It is proved that L. scutellare can be a transmitting vector of HFRS and tsutsugamushi disease of autumn-type and was the dominant species of chigger mite on rats. Expand
Serum macrophage migration‐inhibitory factor as a diagnostic and prognostic biomarker for gastric cancer
This study aimed to determine the potential diagnostic value of migration‐inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer.
PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer
Novel insights are provided into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment and their specific mechanisms and functions need further investigation. Expand
Physical exercise attenuates age‐associated reduction in endothelium‐reparative capacity of endothelial progenitor cells by increasing CXCR4/JAK‐2 signaling in healthy men
It is demonstrated for the first time that physical exercise attenuates age‐associated reduction in endothelium‐reparative capacity of EPCs by increasing CXCR4/JAK‐2 signaling. Expand
Serum SALL4 Is a Novel Prognosis Biomarker with Tumor Recurrence and Poor Survival of Patients in Hepatocellular Carcinoma
High SALL4 serum levels are a novel biomarker in the prognosis of HCC patients showing high prognosis, evidenced by both tumor recurrence and overall survival rate. Expand
Shear stress-induced activation of Tie2-dependent signaling pathway enhances reendothelialization capacity of early endothelial progenitor cells.
The present findings demonstrate for the first time that Tie2/PI3k/Akt/eNOS signaling pathway is, at least in part, involved in the EPCs-mediated reendothelialization after arterial injury. Expand