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Gene expression signatures for predicting prognosis of squamous cell and adenocarcinomas of the lung.
TLDR
The SCC classifier was combined with the previously identified adenocarcinoma prognostic signature and showed that the combined classifier had a predictive accuracy of 71% in 72 NSCLC samples also showing significant differences in overall survival. Expand
The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment
TLDR
It is shown that a point mutation in the zinc finger transcription factor Th-POK (T-helper-inducing POZ/Krüppel-like factor) is responsible for redirection of class-II-restricted thymocytes to the CD8 lineage in HD mice, indicating that Th- POK is a master regulator of lineage commitment. Expand
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
TLDR
It is found that purified primary murine OBs also support the differentiation of primitive hematopoietic stem cells through lymphoid commitment and subsequent differentiation to all stages of B-cell precursors and mature B cells. Expand
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
TLDR
It is shown that Jhdm1b is a histone H3 lysine 36 (H3K36) demethylase that regulates cell proliferation and senescence through p15Ink4b. Expand
Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signalling and therapeutic targeting.
TLDR
Cell-surface GRP78 has emerged as an important regulator of tumour cell signalling and viability as it forms complexes with a rapidly expanding repertoire of cell-surface protein partners, regulating proliferation, PI3K (phosphoinositide 3-kinase)/Akt signalling and cell viability. Expand
Role of the unfolded protein response regulator GRP78/BiP in development, cancer, and neurological disorders.
TLDR
The discovery of surface localization of GRP78 in cancer cells reveals potential novel function, interaction with cell-surface receptors, and possible therapeutic implications and mouse models reveal that GRP 78 controls maturation and secretion of neuronal factors for proper neural migration and offers neuroprotection. Expand
CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice.
TLDR
It is suggested that both tumor and host CD73 cooperatively protect tumors from incoming antitumor T cells and show the potential of targeting CD73 as a cancer immunotherapy strategy. Expand
CD4-CD8 lineage commitment is regulated by a silencer element at the ThPOK transcription-factor locus.
TLDR
A silencer-dependent model of lineage choice is proposed, whereby inactivation of the DRE silencer by a strong TCR signal leads to CD4 commitment, whereas continued silencer activity leads toCD8 commitment. Expand
Exosome‐Mediated Transfer of miR‐133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth
TLDR
It is found that MSC treatment of rats subjected to middle cerebral artery occlusion significantly increased microRNA 133b (miR‐133b) level in the ipsilateral hemisphere and this study provides the first demonstration that M SCs communicate with brain parenchymal cells and may regulate neurite outgrowth by transfer of miR‐ 133b to neural cells via exosomes. Expand
S100A10, annexin A2, and annexin a2 heterotetramer as candidate plasminogen receptors.
TLDR
The important part that S100A10 plays in plasmin regulation and the role this protein plays in cancer cell invasiveness and metastasis are highlighted. Expand
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