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SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
TLDR
The human SAP30 complex is active in deacetylating core histone octamers, but inactive in de acetylating nucleosomal histones due to the inability of the histone binding proteins R bAp46 and RbAp48 to gain access to nucleosome histones.
Conformational changes of the flavivirus E glycoprotein.
TLDR
Comparison of the E structure in its postfusion state with that in the immature and mature virions shows a rotation about a hinge relating the fusion domain DII to domains DI and DIII.
p53 polymorphism in human papillomavirus-associated Kazakh's esophageal cancer in Xinjiang, China.
AIM To investigate the relationship between p53 codon 72 polymorphism and human papillomavirus (HPV) type 16 infection in Kazakh's esophageal cancer (EC) in Xinjiang, China. METHODS Encoding
An in vivo study of hindfoot 3D kinetics in stage II posterior tibial tendon dysfunction (PTTD) flatfoot based on weight-bearing CT scan
TLDR
Joint instability occurred in the hindfoot in simulated weight-bearing condition in patients with stage II posterior tibial tendon dysfunction (PTTD) flatfoot by analysing the reconstructive three-dimensional computed tomography (CT) image data during simulated Weight-bearing.
The HaeIII and XspI PCR-RFLPs detecting polymorphisms at the goat IGFBP-3 locus
TLDR
This study detected for the first time the polymorphisms of goat IGFBP-3 gene by PCR-SSCP and DNA sequencing methods in 767 samples and described the Hae III and Xsp I PCR-RFLPs methods for detecting EX2_67C>G and IVS2+217G>A mutations, respectively.
Encephalitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody associated demyelination: a single‐center cohort study in Shanghai, China
Besides a distinct spectrum of demyelinating syndromes, encephalitis was observed in patients with myelin oligodendrocyte glycoprotein antibodies (MOG‐abs).
Combination of chemotherapy and gefitinib as first‐line treatment of patients with advanced lung adenocarcinoma and sensitive EGFR mutations: A randomised controlled trial: 1310
TLDR
This data indicates that once the BRCA1/BRCA2 mutation is identified, the B cell reprograming process is likely to be more efficient than the other approaches and the traditional 2D/3D approaches.
Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins.
TLDR
The results of both studies invoked the hypothesis that in vivo TAL1 might act as a negative regulator of microE2 and kappa E2/microE5 sequence motifs by forming a complex with the products of the E2A and HTF4 genes.
Real‐time quantitative reverse transcription–polymerase chain reaction to detect propionibacterial ribosomal RNA in the lymph nodes of Chinese patients with sarcoidosis
TLDR
Findings suggest that propionibacteria might be associated with sarcoidosis granulomatous inflammation, and detection of propionIBacterial rRNA by RT–PCR might possibly distinguish sar coidosis from TB.
Combined Hepatocellular Cholangiocarcinomas; Analysis of a Large Database
TLDR
Combined tumors differ from hepatomas and cholangiocarcinomas in terms of distribution and survival patterns in the population; they should be considered neither cholangsiocARCinomas nor hepatomas.
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