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MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.
- Y. Zhang, J. Zhang, K. Hoeflich, M. Ikura, G. Qing, M. Inouye
- Biology, Medicine
- Molecular cell
- 1 October 2003
Escherichia coli contains operons called "addiction modules," encoding toxin and antitoxin, which are responsible for growth arrest and cell death. Here, we demonstrate that MazF toxin encoded by… Expand
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.
- Y. Zhang, Z. W. Sun, +4 authors D. Reinberg
- Biology, Medicine
- Molecular cell
- 1 June 1998
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Recently, histone acetylation and deacetylation were found to be catalyzed by structurally distinct, multisubunit… Expand
Conformational changes of the flavivirus E glycoprotein.
- Y. Zhang, W. Zhang, +5 authors M. Rossmann
- Biology, Medicine
- Structure
- 1 September 2004
Dengue virus, a member of the Flaviviridae family, has a surface composed of 180 copies each of the envelope (E) glycoprotein and the membrane (M) protein. The crystal structure of an N-terminal… Expand
Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence‐specific and frame‐dependent mRNA cleavage
- Meredith H Prysak, Christopher J Mozdzierz, +4 authors N. Woychik
- Biology, Medicine
- Molecular microbiology
- 1 March 2009
Toxin–antitoxin (TA) systems on the chromosomes of free‐living bacteria appear to facilitate cell survival during intervals of stress by inducing a state of reversible growth arrest. However, upon… Expand
Insights into the mRNA Cleavage Mechanism by MazF, an mRNA Interferase*
- Y. Zhang, J. Zhang, H. Hara, I. Kato, M. Inouye
- Biology, Medicine
- Journal of Biological Chemistry
- 4 February 2005
MazF is an Escherichia coli toxin that is highly conserved among the prokaryotes and plays an important role in growth regulation. When MazF is induced, protein synthesis is effectively inhibited.… Expand
Structural mechanism of transcriptional autorepression of the Escherichia coli RelB/RelE antitoxin/toxin module.
- Guangyao Li, Y. Zhang, M. Inouye, M. Ikura
- Biology, Medicine
- Journal of molecular biology
- 27 June 2008
The Escherichia coli chromosomal relBE operon encodes a toxin-antitoxin system, which is autoregulated by its protein products, RelB and RelE. RelB acts as a transcriptional repressor and RelE… Expand
NBK/BIK antagonizes MCL-1 and BCL-XL and activates BAK-mediated apoptosis in response to protein synthesis inhibition.
- Tsutomu Shimazu, K. Degenhardt, +6 authors M. Inouye
- Biology, Medicine
- Genes & development
- 15 April 2007
Ribonucleases, antibiotics, bacterial toxins, and viruses inhibit protein synthesis, which results in apoptosis in mammalian cells. How the BCL-2 family of proteins regulates apoptosis in response to… Expand
Interference of mRNA Function by Sequence-specific Endoribonuclease PemK*
- J. Zhang, Y. Zhang, L. Zhu, M. Suzuki, M. Inouye
- Biology, Medicine
- Journal of Biological Chemistry
- 14 May 2004
In Escherichia coli, programmed cell death is mediated through the system called “addiction module,” which consists of a pair of genes encoding a stable toxin and a labile antitoxin. The pemI-pemK… Expand
Characterization of the Interactions within the mazEF Addiction Module of Escherichia coli*
In bacteria, programmed cell death is mediated through the unique genetic system called “addiction module,” which consists of a pair of genes encoding a stable toxin and an unstable antitoxin. The… Expand
The Inhibitory Mechanism of Protein Synthesis by YoeB, an Escherichia coli Toxin*
YoeB is a toxin encoded by the yefM-yoeB antitoxin-toxin operon in the Escherichia coli genome. Here we show that YoeB, a highly potent protein synthesis inhibitor, specifically blocks translation… Expand