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siRNA Versus miRNA as Therapeutics for Gene Silencing
This review provides a comparison between therapeutic siRNAs and miRNAs in terms of their mechanisms of action, physicochemical properties, delivery, and clinical applications and the challenges in developing both classes of RNA as therapeutics. Expand
A fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) for the detection of mecA gene sequence of Staphylococcus aureus.
In this work, a novel fluorescence resonance energy transfer (FRET) biosensor based on graphene quantum dots (GQDs) and gold nanoparticles (AuNPs) pairs was developed for Staphylococcus aureusExpand
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
It is reported that downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Expand
Comparative proteome and phosphoproteome analyses during cyprid development of the barnacle Balanus (=Amphibalanus) amphitrite.
The data suggest that proteins involved in stress regulation and energy metabolism play crucial roles in regulating larval attachment and metamorphosis of B. amphitrite. Expand
Interference and Molecular Transport-A Dynamical View: Time-Dependent Analysis of Disubstituted Benzenes.
This work uses the simplest electronic structure model to examine the coherent time-dependent transport through meta- and para-linked benzene circuits, and the effects of decoherence, and finds that the phase-caused coherence/decoherence behavior is established very quickly and the localized dephasing at any site reduces the destructive interference of the meta-linked species. Expand
Vitamin D3 activates the autolysosomal degradation function against Helicobacter pylori through the PDIA3 receptor in gastric epithelial cells
These findings provide a novel pathogenic mechanism on how H. pylori can survive in the gastric epithelium, and a unique pathway for vitamin D3 to reactivate the autolysosomal degradation function, which is critical for the antibacterial action of Vitamin D3 both in cells and in animals, and perhaps further in humans. Expand
The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite
It is concluded that NO regulates larval settlement via mediating downstream cGMP signaling and the settlement inhibition effects of SNP could be attenuated by ODQ at all concentrations tested. Expand
Quantum-Mechanical Prediction of Nanoscale Photovoltaics.
Within the nonequilibrium Green's function formalism, a quantum-mechanical study of the performance of inorganic nanowire-based photovoltaic devices is presented, on the basis of density-functional tight-binding theory. Expand
2D gel-based multiplexed proteomic analysis during larval development and metamorphosis of the biofouling polychaete tubeworm Hydroides elegans.
The results indicated that the level of protein phosphorylation might play a crucial role in the initiation of larval settlement and metamorphosis of H. elegans. Expand
The potential of the human immune system to develop broadly neutralizing HIV-1 antibodies: implications for vaccine development
The human gDNA antibody gene repertoires may have more potential than the cDNA repertoires to develop HIV-1 bnAbs, indicating that the human gDNAs and mRNAs isolated from uninfected and HIV- 1-infected human peripheral blood mononuclear cells were more diverse in heavy and light chain V-gene lineage usage than thecDNA libraries. Expand