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Production of offspring from a germline stem cell line derived from neonatal ovaries
The idea that females of most mammalian species have lost the capacity for oocyte production at birth has been challenged recently by the finding that juvenile and adult mouse ovaries possessExpand
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Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo
We assess the role of intrinsic histone-DNA interactions by mapping nucleosomes assembled in vitro on genomic DNA. Nucleosomes strongly prefer yeast DNA over Escherichia coli DNA, indicating that theExpand
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Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
Target of Rapamycin (TOR) mediates a signalling pathway that couples amino acid availability to S6 kinase (S6K) activation, translational initiation and cell growth. Here, we show that tuberousExpand
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Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
White adipocytes have a unique structure in which nearly the entire cell volume is occupied by one large lipid droplet. However, the molecular and cellular processes involved in the cytoplasmicExpand
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Genome-wide in silico identification and analysis of cis natural antisense transcripts (cis-NATs) in ten species
We developed a fast, integrative pipeline to identify cis natural antisense transcripts (cis-NATs) at genome scale. The pipeline mapped mRNAs and ESTs in UniGene to genome sequences in GoldenPath toExpand
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Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors
RationaleSalvinorin A is a naturally occurring hallucinogen derived from the plant Salvia divinorum. Salvinorin A is also a potent and selective kappa opioid receptor agonist in vitro. It has beenExpand
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A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases.
Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptionalExpand
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Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines.
AIMS The present study was designed to decipher molecular mechanisms underlying nicotine's promoting atrial fibrillation (AF) by inducing atrial structural remodelling. METHODS AND RESULTS TheExpand
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Screening of potential probiotic properties of Lactobacillus fermentum isolated from traditional dairy products
Ninety strains of Lactobacillus fermentum which were isolated from traditional dairy products of minority nationalities (53 strains from Tibet, 1 from Inner Mongolia, 7 from Yun Nan and 29 fromExpand
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Identifying Positioned Nucleosomes with Epigenetic Marks in Human from ChIP-Seq
BackgroundIn vivo positioning and covalent modifications of nucleosomes play an important role in epigenetic regulation, but genome-wide studies of positioned nucleosomes and their modifications inExpand
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