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Copy Number Amplification of the PIK3CA Gene Is Associated with Poor Prognosis in Non-lymph node metastatic Head and Neck Squamous Cell Carcinoma
BackgroundDeregulation of the EGFR signaling pathway is one of the most frequently observed genetic abnormalities that drives cancer development. Although mutations in the downstream components ofExpand
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Antitumor activity of G-quadruplex-interactive agent TMPyP4 in K562 leukemic cells.
The cationic porphyrin TMPyP4 can bind to and stabilize DNA guanine-quadruplexes. We investigated the molecular mechanism of the antitumor activity of TMPyP4 in K562 cells and human telomere reverseExpand
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Validation of the Japanese version of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module
BackgroundThe PedsQL 3.0 Cancer Module is a widely used instrument to measure pediatric cancer specific health-related quality of life (HRQOL) for children aged 2 to 18 years. We developed theExpand
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Hematopoietic stem cell transplantation for progressive combined immunodeficiency and lymphoproliferation in patients with activated phosphatidylinositol‐3‐OH kinase &dgr; syndrome type 1
Background: Activated phosphatidylinositol‐3‐OH kinase &dgr; syndrome type 1 (APDS1) is a recently described primary immunodeficiency syndrome characterized by recurrent respiratory tract infections,Expand
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Successful treatment of Diamond‐Blackfan anemia with metoclopramide
Diamond‐Blackfan anemia (DBA) is a congenital anemia characterized by a low reticulocyte count, the absence or severe reduction of hemoglobin‐containing cells in the bone marrow, and normalExpand
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High event‐free survival rate with minimum‐dose‐anthracycline treatment in childhood acute promyelocytic leukaemia: a nationwide prospective study by the Japanese Paediatric Leukaemia/Lymphoma Study
We evaluated the efficacy of treatment using reduced cumulative doses of anthracyclines in children with acute promyelocytic leukaemia (APL) in the Japanese Paediatric Leukaemia/Lymphoma Study GroupExpand
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Rapid spontaneous regression of multicentric infantile myofibromatosis in the posterior fossa and lumbar vertebra
Infantile myofibromatosis is the most common fibrous tumor of infancy and early childhood. It typically occurs in skin, subcutaneous tissue, muscle, bone, and/or viscera. In patients without visceralExpand
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Residual disease detected by multidimensional flow cytometry shows prognostic significance in childhood acute myeloid leukemia with intermediate cytogenetics and negative FLT3-ITD: a report from the
Residual disease (RD) after induction chemotherapy may predict clinical outcome in acute myeloid leukemia (AML). In the present study, we investigated the prognostic significance of RD detected byExpand
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Impact of graft-versus-host disease on relapse and survival after allogeneic stem cell transplantation for pediatric leukemia
Graft-versus-host disease (GVHD) occasionally leads to morbidity and mortality but is thought to reduce the risk of relapses in patients with a hematological malignancy. However, information on theExpand
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Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese
Genome-wide association studies (GWAS) performed mostly in populations of European and Hispanic ancestry have confirmed an inherited genetic basis for childhood acute lymphoblastic leukemia (ALL),Expand
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