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Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis
Abnormal metabolism of nonesterified fatty acids (NEFAs) and their derivatives has been reported to be the main cause of intracellular lipotoxic injury. Normally, NEFAs are stored in lipid dropletsExpand
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A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma
Post-translational modifications of histones alter chromatin structure and play key roles in gene expression and specification of cell states. Small molecules that target chromatin-modifying enzymesExpand
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Progressive impairment of muscle regeneration in muscleblind-like 3 isoform knockout mice.
The muscleblind-like (MBNL) genes encode alternative splicing factors that are essential for the postnatal development of multiple tissues, and the inhibition of MBNL activity by toxic C(C)UG repeatExpand
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Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.
Lung cancer characterized with malignant cell growth is the leading cause of cancer-related deaths. In recent years, several circular RNAs (circRNAs) have been reported to participate in lung cancerExpand
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Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues
The link between microbiota and gastric cancer (GC) has attracted widespread attention. However, the phylogenetic profiles of niche-specific microbiota in the tumor microenvironment is still unclear.Expand
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Intraflagellar transport 88 (IFT88) is crucial for craniofacial development in mice and is a candidate gene for human cleft lip and palate
Abstract Ciliopathies are pleiotropic human diseases resulting from defects of the primary cilium, and these patients often have cleft lip and palate. IFT88 is required for the assembly and functionExpand
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CircRNAs and its relationship with gastric cancer
Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outlineExpand
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Protection against cardiac hypertrophy by geniposide involves the GLP‐1 receptor / AMPKα signalling pathway
Activation of glucagon‐like peptide‐1 (GLP‐1) receptor exerts a range of cardioprotective effects. Geniposide is an agonist of GLP‐1 receptor, but its role in cardiac hypertrophy remains completelyExpand
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Hesperetin attenuates mitochondria-dependent apoptosis in lipopolysaccharide-induced H9C2 cardiomyocytes.
Apoptosis is closely associated with the occurrence and development of cardiovascular diseases and is considered as one of the crucial pathological processes of cardiomyopathy, sepsis,Expand
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SNHG7 accelerates cell migration and invasion through regulating miR-34a-Snail-EMT axis in gastric cancer
ABSTRACT Small nucleolar RNA host gene 7 (SNHG7) is a newly recognized oncogenic Long non-coding RNA (lncRNA) in most human cancers. In gastric cancer, SNHG7 has been suggested to enhance cellExpand
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