Y. Yuan

Publications41
h-index19
Citations985
Highly Influential Citations35
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Dravet syndrome patient‐derived neurons suggest a novel epilepsy mechanism
Neuronal channelopathies cause brain disorders, including epilepsy, migraine, and ataxia. Despite the development of mouse models, pathophysiological mechanisms for these disorders remain uncertain.… Expand
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Expression and permeation properties of the K+ channel Kir7.1 in the retinal pigment epithelium
1 Bovine Kir7.1 clones were obtained from a retinal pigment epithelium (RPE)‐subtracted cDNA library. Human RPE cDNA library screening resulted in clones encoding full‐length human Kir7.1. 2 Northern… Expand
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Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability
Voltage-gated Na+ channel (VGSC) β1 subunits, encoded by SCN1B, are multifunctional channel modulators and cell adhesion molecules (CAMs). Mutations in SCN1B are associated with the genetic epilepsy… Expand
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Gene expression profile of native human retinal pigment epithelium.
PURPOSE To generate a profile of genes expressed in the native human retinal pigment epithelium and identify candidate genes for retinal and macular diseases. METHODS Two cDNA libraries (one… Expand
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Neuronal hyperexcitability in a mouse model of SCN8A epileptic encephalopathy
Significance Patients with early infantile epileptic encephalopathy experience severe seizures and cognitive impairment and are at increased risk for sudden unexpected death in epilepsy (SUDEP).… Expand
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Kinetic effects of FPL 64176 on L-type Ca2+ channels in cardiac myocytes
Abstract. To characterize the effects of the Ca2+ channel agonist FPL 64176 on L-type Ca2+ current in isolated rat ventricular myocytes, certain of its effects were compared with those of a better… Expand
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Exposure to an Environmental Neurotoxicant Hastens the Onset of Amyotrophic Lateral Sclerosis-Like Phenotype in Human Cu2+/Zn2+ Superoxide Dismutase 1 G93A Mice: Glutamate-Mediated Excitotoxicity
Mice expressing the human Cu2+/Zn2+ superoxide dismutase 1 (hSOD1) gene mutation (hSOD1G93A; G93A) were exposed to methylmercury (MeHg) at concentrations that did not cause overt motor dysfunction.… Expand
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Regulation of Inwardly Rectifying K+ Channels in Retinal Pigment Epithelial Cells by Intracellular pH
Inwardly rectifying K+ (Kir) channels in the apical membrane of the retinal pigment epithelium (RPE) play a key role in the transport of K+ into and out of the subretinal space (SRS), a small… Expand
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Allethrin differentially modulates voltage-gated calcium channel subtypes in rat PC12 cells.
Pyrethroid insecticides are one of the most widely used classes of insecticides. Previous studies revealed that pyrethroids potently affect the insect voltage-gated sodium (Na(+)) channel (VGSC),… Expand
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Edge-emitting lasers with short-period semiconductor/air distributed Bragg reflector mirrors
We demonstrate a short-cavity edge-emitting 0.98-/spl mu/m GaAs-based laser with semiconductor/air distributed Bragg reflector (DBR) mirrors made by reactive ion etching (RIE). The dc and… Expand
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