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A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
Mycobacterium tuberculosis, which causes tuberculosis, is the greatest single infectious cause of mortality worldwide, killing roughly two million people annually. Estimates indicate that one-thirdExpand
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Silencing SOX2 Induced Mesenchymal-Epithelial Transition and Its Expression Predicts Liver and Lymph Node Metastasis of CRC Patients
SOX2 is an important stem cell marker and plays important roles in development and carcinogenesis. However, the role of SOX2 in Epithelial-Mesenchymal Transition has not been investigated. WeExpand
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IDH mutation status and role of WHO grade and mitotic index in overall survival in grade II–III diffuse gliomas
Diffuse gliomas are up till now graded based upon morphology. Recent findings indicate that isocitrate dehydrogenase (IDH) mutation status defines biologically distinct groups of tumors. The role ofExpand
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Physicochemical and spectroscopic characteristics of dissolved organic matter extracted from municipal solid waste (MSW) and their influence on the landfill biological stability.
For the purpose of evaluating the stability of municipal solid waste (MSW) excavated from a landfill, dissolved organic matter was extracted and characterized by physicochemical and spectroscopicExpand
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Different treatment strategies and molecular features between right-sided and left-sided colon cancers.
The colon is derived from the embryological midgut and hindgut separately, with the right colon and left colon having different features with regards to both anatomical and physiologicalExpand
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Activity-Dependent Modulation of Odorant Receptor Gene Expression in the Mouse Olfactory Epithelium
Activity plays critical roles in development and maintenance of the olfactory system, which undergoes considerable neurogenesis throughout life. In the mouse olfactory epithelium, each olfactoryExpand
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A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor‐Initiating Cells
Genomic, transcriptional, and proteomic analyses of brain tumors reveal subtypes that differ in pathway activity, progression, and response to therapy. However, a number of small molecule inhibitorsExpand
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The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA
Achyranthes bidentata Blume is a commonly prescribed Chinese medicinal herb with a variety of pharmaceutical properties. From its aqueous extract we have separated important constituents, referred toExpand
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A novel image encryption algorithm based on chaos and Line map
We propose a novel symmetrical image encryption algorithm based on skew tent map. Expand
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Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial
Importance Patients with metastatic colorectal cancer (CRC) have limited effective and tolerable treatment options. Objective To evaluate the efficacy and safety of oral fruquintinib, a vascularExpand
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