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The neuronal architecture of the mushroom body provides a logic for associative learning
We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each ofExpand
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MicroRNA-Mediated Control of Oligodendrocyte Differentiation
MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive. To determine the role ofExpand
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Neurons for hunger and thirst transmit a negative-valence teaching signal
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, butExpand
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miR-146a controls the resolution of T cell responses in mice
By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.
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11&bgr;-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation
Aldosterone stimulates the sympathetic nervous system by binding to a select population of brain mineralocorticoid receptors (MR). These MR have an equal affinity for corticosterone that is presentExpand
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mGRASP enables mapping mammalian synaptic connectivity with light microscopy
The GFP reconstitution across synaptic partners (GRASP) technique, based on functional complementation between two nonfluorescent GFP fragments, can be used to detect the location of synapsesExpand
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Evidence that microRNAs are associated with translating messenger RNAs in human cells
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3′ untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentiallyExpand
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Transforming growth factor β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to as cancer-initiating or cancer stem cells (CSCs), have crucial roles in tumor initiation, metastasisExpand
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Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation*
  • Yihui Fan, Y. Yu, +11 authors J. Yang
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 28 December 2009
Transforming growth factor-β-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor α (TNFα)- and interleukin-1β (IL-1β)-induced IκB kinase (IKK)/nuclear factor-κB (NF-κB) andExpand
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PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
IKKbeta serves as a central intermediate signaling molecule in the activation of the NF-kappaB pathway. However, the precise mechanism for the termination of IKKbeta activity is still not fullyExpand
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