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- Publications
- Influence
The neuronal architecture of the mushroom body provides a logic for associative learning
- Y. Aso, D. Hattori, +8 authors G. Rubin
- Biology, Medicine
- eLife
- 23 December 2014
We identified the neurons comprising the Drosophila mushroom body (MB), an associative center in invertebrate brains, and provide a comprehensive map describing their potential connections. Each of… Expand
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
- Xianghui Zhao, X. He, +10 authors Q. Lu
- Biology, Medicine
- Neuron
- 11 March 2010
MicroRNAs (miRNAs) regulate various biological processes, but evidence for miRNAs that control the differentiation program of specific neural cell types has been elusive. To determine the role of… Expand
Neurons for hunger and thirst transmit a negative-valence teaching signal
- J. Betley, S. Xu, +4 authors S. Sternson
- Biology, Medicine
- Nature
- 27 April 2015
Homeostasis is a biological principle for regulation of essential physiological parameters within a set range. Behavioural responses due to deviation from homeostasis are critical for survival, but… Expand
miR-146a controls the resolution of T cell responses in mice
- L. Yang, M. Boldin, +6 authors D. Baltimore
- Biology, Medicine
- The Journal of experimental medicine
- 27 August 2012
By suppressing expression of TRAF6 and IRAK1, miR-146a regulates NF-κB activation in T cells through a negative feedback loop and controls the resolution of T cell responses in mice.
11&bgr;-Hydroxysteroid Dehydrogenase Type 2 Activity in Hypothalamic Paraventricular Nucleus Modulates Sympathetic Excitation
- Zhi-hua Zhang, Y. Kang, +4 authors R. Felder
- Biology, Medicine
- Hypertension
- 1 July 2006
Aldosterone stimulates the sympathetic nervous system by binding to a select population of brain mineralocorticoid receptors (MR). These MR have an equal affinity for corticosterone that is present… Expand
mGRASP enables mapping mammalian synaptic connectivity with light microscopy
- Jinhyun Kim, Ting Zhao, +4 authors J. Magee
- Biology, Medicine
- Nature Methods
- 2012
The GFP reconstitution across synaptic partners (GRASP) technique, based on functional complementation between two nonfluorescent GFP fragments, can be used to detect the location of synapses… Expand
Evidence that microRNAs are associated with translating messenger RNAs in human cells
- P. A. Maroney, Y. Yu, Jesse Fisher, T. Nilsen
- Biology, Medicine
- Nature Structural &Molecular Biology
- 26 November 2006
MicroRNAs (miRNAs) regulate gene expression post-transcriptionally by binding the 3′ untranslated regions of target mRNAs. We examined the subcellular distribution of three miRNAs in exponentially… Expand
Transforming growth factor β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM
- Yujun Wang, Y. Yu, +5 authors S. Wang
- Biology, Medicine
- Oncogene
- 19 October 2010
Recent studies indicate that a subset of cancer cells possessing stem cell properties, referred to as cancer-initiating or cancer stem cells (CSCs), have crucial roles in tumor initiation, metastasis… Expand
Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation*
- Yihui Fan, Y. Yu, +11 authors J. Yang
- Biology, Medicine
- The Journal of Biological Chemistry
- 28 December 2009
Transforming growth factor-β-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor α (TNFα)- and interleukin-1β (IL-1β)-induced IκB kinase (IKK)/nuclear factor-κB (NF-κB) and… Expand
PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation.
IKKbeta serves as a central intermediate signaling molecule in the activation of the NF-kappaB pathway. However, the precise mechanism for the termination of IKKbeta activity is still not fully… Expand