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How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicity in Vitro♦
TLDR
The small molecule EGCG, which inhibits α-synuclein oligomer toxicity, moderately reduces membrane binding and immobilizing the oligomer C-terminal tail suggests that reduction of the membrane affinity of the oligomers is sufficient to prevent cytotoxicity.
Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker.
TLDR
Radioiodine-labeled ITdU is potentially useful as a proliferation-imaging agent, and further studies should clarify the usefulness of this compound as a tumor-imaged agent.
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
TLDR
By monitoring the kinetics of the formation of amyloid fibrils and glass-like amorphous aggregates, it is shown that solubility and supersaturation will be key factors for further understanding the aberrant aggregation of proteins.
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions
TLDR
NMR chemical shift perturbations demonstrate that a positively charged segment of MOAG-4 forms a transiently populated α-helix that interacts with the negatively charged C terminus of α-Syn, resulting in the protein populating less compact forms and aggregating more readily.
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.
We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives was achieved
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils
TLDR
It is presented that ultrasonication pulses are useful for preparing monodispersed amyloid fibrils of minimal size with an average molecular weight of ≈1,660,000 (140-mer).
Detecting O2 binding sites in protein cavities
TLDR
O2 gas-pressure NMR measurements can detect hydrophobic cavities when populated to as little as 1%, and thereby provide a general and highly sensitive method for detecting oxygen binding in proteins, the first experimental demonstration that O2 binds specifically to the hydrophilic cavities in a protein.
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