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How Epigallocatechin Gallate Can Inhibit α-Synuclein Oligomer Toxicity in Vitro♦
- Nikolai Lorenzen, S. Nielsen, D. Otzen
- Biology, MedicineThe Journal of Biological Chemistry
- 6 June 2014
The small molecule EGCG, which inhibits α-synuclein oligomer toxicity, moderately reduces membrane binding and immobilizing the oligomer C-terminal tail suggests that reduction of the membrane affinity of the oligomers is sufficient to prevent cytotoxicity.
Rationale of 5-(125)I-iodo-4'-thio-2'-deoxyuridine as a potential iodinated proliferation marker.
- J. Toyohara, Akio Hayashi, Y. Fujibayashi
- Biology, ChemistryJournal of nuclear medicine : official…
- 1 September 2002
Radioiodine-labeled ITdU is potentially useful as a proliferation-imaging agent, and further studies should clarify the usefulness of this compound as a tumor-imaged agent.
Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
- Y. Yoshimura, Yuxi Lin, Y. Goto
- Chemistry, Materials ScienceProceedings of the National Academy of Sciences
- 20 August 2012
By monitoring the kinetics of the formation of amyloid fibrils and glass-like amorphous aggregates, it is shown that solubility and supersaturation will be key factors for further understanding the aberrant aggregation of proteins.
The monomer-seed interaction mechanism in the formation of the β2-microglobulin amyloid fibril clarified by solution NMR techniques.
MOAG-4 promotes the aggregation of α-synuclein by competing with self-protective electrostatic interactions
- Y. Yoshimura, M. Holmberg, F. Mulder
- Biology, ChemistryThe Journal of Biological Chemistry
- 23 March 2017
NMR chemical shift perturbations demonstrate that a positively charged segment of MOAG-4 forms a transiently populated α-helix that interacts with the negatively charged C terminus of α-Syn, resulting in the protein populating less compact forms and aggregating more readily.
Comparison of 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity.
α-1-C-butyl-1,4-dideoxy-1,4-imino-l-arabinitol as a second-generation iminosugar-based oral α-glucosidase inhibitor for improving postprandial hyperglycemia.
We report on the synthesis and the biological evaluation of a series of α-1-C-alkylated 1,4-dideoxy-1,4-imino-l-arabinitol (LAB) derivatives. The asymmetric synthesis of the derivatives was achieved…
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils
- E. Chatani, Young-Ho Lee, H. Yagi, Y. Yoshimura, H. Naiki, Y. Goto
- Biology, ChemistryProceedings of the National Academy of Sciences
- 7 July 2009
It is presented that ultrasonication pulses are useful for preparing monodispersed amyloid fibrils of minimal size with an average molecular weight of ≈1,660,000 (140-mer).
Antitumor activity of a novel orally effective nucleoside, 1-(2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranosyl)cytosine.
Detecting O2 binding sites in protein cavities
- R. Kitahara, Y. Yoshimura, Mengjun Xue, T. Kameda, F. Mulder
- Chemistry, BiologyScientific reports
- 2 February 2016
O2 gas-pressure NMR measurements can detect hydrophobic cavities when populated to as little as 1%, and thereby provide a general and highly sensitive method for detecting oxygen binding in proteins, the first experimental demonstration that O2 binds specifically to the hydrophilic cavities in a protein.