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Stem Cell-Like Properties of the Endometrial Side Population: Implication in Endometrial Regeneration
Background The human endometrium undergoes cyclical regeneration throughout a woman's reproductive life. Ectopic implantation of endometrial cells through retrograde menstruation gives rise to… Expand
Nonendothelial Source of Nitric Oxide in Arterioles But Not in Venules: Alternative Source Revealed In Vivo by Diaminofluorescein Microfluorography
- S. Kashiwagi, M. Kajimura, Y. Yoshimura, M. Suematsu
- Chemistry, Medicine
- Circulation research
- 13 December 2002
Abstract— This study aimed to examine topographic distribution of microvascular NO generation in vivo. To this end, nitrosonium ion (NO+)–sensitive diaminofluorescein diacetate was superfused… Expand
Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtype.
The present study was undertaken to investigate the role of angiotensin II (Ang II) in ovulation and ovarian steroidogenesis and prostaglandin (PG) production via the Ang II receptors in rabbit… Expand
Involvement of Histone Acetylation in Ovarian Steroid-induced Decidualization of Human Endometrial Stromal Cells*
- N. Sakai, T. Maruyama, +7 authors Y. Yoshimura
- Biology, Medicine
- The Journal of Biological Chemistry
- 9 May 2003
Histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones, regulating gene transcription. Decidualization is the progestin-induced differentiation of… Expand
Leydig cell-derived heme oxygenase-1 regulates apoptosis of premeiotic germ cells in response to stress.
- N. Ozawa, N. Goda, N. Makino, T. Yamaguchi, Y. Yoshimura, M. Suematsu
- The Journal of clinical investigation
Stress-induced downregulation of spermatogenesis remains poorly understood. This study examined the induction of heme oxygenase-1 (HO-1), a carbon monoxide-generating inducible enzyme, in modulation… Expand
Involvement of angiotensin II in the process of gonadotropin-induced ovulation in rabbits.
In the present study we investigated the role of angiotensin II (Ang II) receptor subtypes in gonadotropin-induced ovulation, oocyte maturation, and ovarian steroidogenesis and prostaglandin (PG)… Expand
Rapid replacement of somatic linker histones with the oocyte-specific linker histone H1foo in nuclear transfer.
- Takahide Teranishi, M. Tanaka, +4 authors Y. Yoshimura
- Medicine, Biology
- Developmental biology
- 1 February 2004
The most distinctive feature of oocyte-specific linker histones is the specific timing of their expression during embryonic development. In Xenopus nuclear transfer, somatic linker histones in the… Expand
Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin.
- H. Uchida, T. Maruyama, Takashi Nagashima, H. Asada, Y. Yoshimura
- Biology, Medicine
- 1 December 2005
Histone reversible acetylation, which is controlled by histone acetyltransferases and deacetylases, plays a fundamental role in gene transcription. Histone deacetylase inhibitors (HDACIs), such as… Expand
Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells
- M. Ono, T. Maruyama, +10 authors Y. Matsuzaki
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 20 November 2007
Over the course of pregnancy, the human uterus undergoes a 500- to 1,000-fold increase in volume and a 24-fold increase in weight. The uterine smooth muscle layer or myometrium is remodeled, and both… Expand
Human uterine stem/progenitor cells: their possible role in uterine physiology and pathology.
The human uterus mainly consists of the endometrium and the outer smooth muscle layer termed the myometrium. The uterus harbours the exceptional and remarkable regenerative ability responsible for… Expand