Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2
- Y. Yokota, A. Mansouri, P. Gruss
- BiologyNature
- 25 February 1999
It is shown that Id2 is indispensable for normal development of mice and has an essential role in the generation of peripheral lymphoid organs and NK cells.
Transcriptional profiling identifies Id2 function in dendritic cell development
- Christine Hacker, Ralf D. Kirsch, M. Zenke
- BiologyNature Immunology
- 24 February 2003
It is found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo and a TGF-β–Id2 signaling pathway in DCs is revealed, suggesting a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors.
Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity
The mechanism by which Id2 functions is defined, showing that a reduction in E protein activity, through deletion of E2A, overcomes the need for Id2 in development of BM mNK cells, LTi cells, and secondary lymphoid tissues.
The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression
- H. Gonda, M. Sugai, A. Shimizu
- BiologyJournal of Experimental Medicine
- 3 November 2003
It is shown that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expression of activation-induced cytidine deaminase (AID), which has been shown to be indispensable for CSR.
A Role for the Helix-Loop-Helix Protein Id2 in the Control of Oligodendrocyte Development
- Songli Wang, A. Sdrulla, Jane E. Johnson, Y. Yokota, B. Barres
- BiologyNeuron
- 1 March 2001
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5
- S. Uematsu, K. Fujimoto, S. Akira
- BiologyNature Immunology
- 1 July 2008
These findings demonstrate unique properties of LPDCs and the importance of TLR5 for adaptive immunity in the intestine and positively regulated the differentiation interleukin 17–producing T helper cells.
Two distinct types of Langerhans cells populate the skin during steady state and inflammation.
- K. Seré, Jea-Hyun Baek, T. Hieronymus
- BiologyImmunity
- 16 November 2012
Transcription-Coupled Events Associating with Immunoglobulin Switch Region Chromatin
- Y. Nambu, M. Sugai, A. Shimizu
- BiologyScience
- 19 December 2003
The results indicate an important role of GLT in the regulation of chromatin accessibility, strongly suggesting that the target of AID is chromatin DNA.
Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1.
- G. Bai, Nengyin Sheng, N. Jing
- BiologyDevelopmental Cell
- 7 August 2007
Cloning and expression of cDNA for a human thromboxane A2 receptor
- M. Hirata, Y. Hayashi, S. Narumiya
- BiologyNature
- 14 February 1991
This first report on the molecular structure of an eicosanoid receptor will promote the molecular pharmacology and pathophysiology of these bioactive compounds.
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