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Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells.
The totipotent stem cells of the pregastrulation mouse embryo which give rise to all embryonic somatic tissues and germ cells express Oct-4. The expression is downregulated during gastrulation and isExpand
Germline‐specific expression of the Oct‐4/green fluorescent protein (GFP) transgene in mice
The Pic‐1, Oct‐1,2, Unc‐86 (POU) transcription factor Oct‐4 is specifically expressed in the germ cell line, and a previous study has indicated that the expression of the lacZ gene inserted into anExpand
Epigenomic Analysis of Aberrantly Methylated Genes in Colorectal Cancer Identifies Genes Commonly Affected by Epigenetic Alterations
BackgroundDetermination of the profile of genes that are commonly methylated aberrantly in colorectal cancer (CRC) will have substantial value for diagnostic and therapeutic applications. However,Expand
Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis.
We searched for potential suppressors of tumor metastasis by identifying the genes that are frequently down-regulated in hepatocellular carcinomas (HCC) while being negatively correlated withExpand
Retinoic acid‐mediated down‐regulation of Oct3/4 coincides with the loss of promoter occupancy in vivo.
Oct3/4, a hallmark of the earliest stages of embryogenesis, is expressed in undifferentiated embryonal carcinoma (EC) and embryonic stem (ES) cells. Oct3/4 gene expression is dependent on theExpand
A Lactate-Induced Response to Hypoxia
Organisms must be able to respond to low oxygen in a number of homeostatic and pathological contexts. Regulation of hypoxic responses via the hypoxia-inducible factor (HIF) is well established, butExpand
Effect of polyethylene glycol on gene delivery of polyethylenimine.
Polyethylene glycol (PEG) has been coupled to many cationic polymers such as polyethylenimine (PEI) to improve the stability and transfection efficiency. We prepared PEG-grafted PEI with differentExpand
Structure, expression and chromosomal location of the Oct-4 gene
The map position of Oct-4 on mouse chromosome 17 is between Q and T regions in the Major Histocompatibility Complex (MHC), and it is physically located within 35 kb of a class I gene. SeveralExpand
Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines.
Osteopontin (OPN, SPP1) is a secretory extracellular matrix protein that has been implicated in cancer-associated mechanisms such as metastasis, invasion and angiogenesis. Three OPN isoforms (OPN-a,Expand
Evaluation of annexin II as a potential serum marker for hepatocellular carcinoma using a developed sandwich ELISA method.
  • N. Ji, M. Park, +10 authors E. Song
  • Biology, Medicine
  • International journal of molecular medicine
  • 1 December 2009
Annexin II (Annexin A2, ANXA2) is a 36 kDa calcium-dependent phospholipid-binding protein that is located on the surface of most eukaryotic cells. ANXA2 is involved in several biological processes,Expand
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