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Metabolite cumulation during chronic propafenone dosing in arrhythmia
The cumulation of propafenone and two of its metabolites, 5‐hydroxypropafenone (5‐OHP) and N‐depropylpropafenone (NDPP), was examined in patients with frequent ventricular ectopy. After 2 weeks ofExpand
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Influence of congestive heart failure on prazosin kinetics
The kinetics of oral prazosin was studied in 10 healthy normal subjects (NS) and in 9 patients with congestive heart failure (CHF). NS received a single 5‐mg dose, and blood concentrations ofExpand
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Prazosin determination by high-pressure liquid chromatography using fluorescence detection.
A high-pressure liquid chromatographic procedure using fluorescence detection for the analysis of prazosin in whole blood and plasma is described. It employs a simple and rapid method of sampleExpand
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Atenolol determination by high-performance liquid chromatography and fluorescence detection.
A high-performance liquid chromatographic procedure using a fluorescence detector for the analysis of atenolol in plasma and whole blood is described. It employs a simple and rapid method ofExpand
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High-pressure liquid chromatographic analysis of drugs in biological fluids. V. Analysis of acebutolol and its major metabolite.
A high-pressure liquid chromatographic analysis for acebutolol and its major metabolite in blood, plasma and urine is reported. The analysis, in which the above mentioned compounds areExpand
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Verapamil protein binding in patients and in normal subjects
Verapamil plasma protein binding was studied in four groups of 12 subjects each: (1) normal subjects; (2) patients with moderate renal insufficiency and patients requiring dialysis; (3) patients 1 toExpand
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Effect of albumin on the electrophysiologic stability of isolated perfused rabbit hearts.
The electrophysiologic stability of isolated perfused rabbit hearts was evaluated over a period of 5 h. Hearts perfused with protein-free buffer deteriorated over time, with significant shortening ofExpand
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Interaction between warfarin and propafenone in healthy volunteer subjects
The effect of propafenone on the pharmacokinetics and pharmacologic effects of warfarin was studied in healthy normal male volunteer subjects. Each drug was administered alone for 1 week followed byExpand
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