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Anti-cancer and analgesic effects of resolvin D2 in oral squamous cell carcinoma
TLDR
It is infer from the results that manipulation of the endogenous pro‐resolution pathway might provide a novel approach to improve oral cancer and cancer pain treatment. Expand
Nerve Growth Factor Links Oral Cancer Progression, Pain, and Cachexia
TLDR
It is shown that NGF blockade decreased tumor proliferation, nociception, and weight loss by orchestrating proinflammatory cytokines and leptin production, and identified NGF as a common link among proliferation, pain, and cachexia in oral cancer. Expand
Re-expression of the methylated EDNRB gene in oral squamous cell carcinoma attenuates cancer-induced pain
TLDR
These findings identify EDNRB methylation as a novel regulatory mechanism in cancer‐induced pain and suggest that demethylation therapy targeted at the cancer microenvironment has the potential to thwart pain‐producing mechanisms at the source, thus freeing patients of systemic analgesic toxicity. Expand
Analgesia targeting IB4-positive neurons in cancer-induced mechanical hypersensitivity.
TLDR
The results demonstrate that peripherally administered pharmacological agents targeting IB4 (+) neurons, such as a selective δ-opioid receptor agonist or P2X(3) antagonist, might be useful in treating oral cancer pain. Expand
Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes
TLDR
Cinobufagin-induced local analgesic effect might be associated with increased activity of POMC/β-END/μ-OR pathway released from invaded CD3/4/8 lymphocytes in cancer tissues. Expand
OPRM1 Methylation Contributes to Opioid Tolerance in Cancer Patients.
TLDR
It is demonstrated that epigenetic regulation of OPRM1 contributes to opioidolerance in cancer patients, and that targeted gene therapy could treat cancer-induced nociception and opioid tolerance in a mouse cancer model. Expand
Alterations in opioid inhibition cause widespread nociception but do not affect anxiety-like behavior in oral cancer mice
TLDR
It is inferred that opioid receptors contribute to widespread nociception in oral cancer mice, and an acute cancer pain model was used to test whether adaptation to chronic pain is responsible for the absence of greater anxiety-like behavior in cancer mice. Expand
Early postnatal loss of heat sensitivity among cutaneous myelinated nociceptors in Swiss-Webster mice.
TLDR
The results show that heat sensitivity is not strictly correlated with other physiological or anatomical properties, most notably mechanical threshold or laminar termination patterns, of myelinated nociceptors at these ages, and there is a marked decline in the number of heat-sensitive myelination mechanonocicePTors (A-mechanoheat nocICEptors [AMHs]) during this early postnatal period. Expand
Reciprocal interactions between cancer and Schwann cells contribute to oral cancer progression and pain
TLDR
Using a non-contact co-culture model, it is demonstrated that Schwann cells (RSC-96) and oral SCC cells (HSC-3) reciprocally interact to promote proliferation, migration, and invasion and that supernatant from the RSC- 96 cells co-cultured with HSC- 3 cells induces increased mechanical hypersensitivity in mice. Expand
Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers
TLDR
These data identify a key peripheral mechanism in cancer pain and highlight the clinical potential of specifically targeting nociceptors expressing both P2X2 and P2x3 subunits (e.g., P 2X2/3 heterotrimers) to alleviate cancer pain. Expand
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