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Advances in saponin-based adjuvants.
This review will summarize the current advances concerning adjuvant effects of different kinds of saponins and the structure-activity relationship of sap onin adjuvants will also be discussed in the light of recent findings. Expand
Furan fatty acid as an anti-inflammatory component from the green-lipped mussel Perna canaliculus
- T. Wakimoto, Hikaru Kondo, +14 authors I. Abe
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 4 October 2011
The in vivo activity of F-acids is reported, confirming that the lipid extract of the green-lipped mussel includes an unstable fatty acid that is more effective than EPA. Expand
Adjuvant effect of Panax notoginseng saponins on the immune responses to ovalbumin in mice.
The results suggest that PNS could be safely used as adjuvant with low or non-haemolytic effect on the cellular and humoral immune responses of ICR mice against ovalbumin. Expand
ISCOMs and ISCOMATRIX.
ISCOMs and ISCOMATRIX vaccines have now been shown to induce strong antigen-specific cellular or humoral immune responses to a broad range of antigens of viral, bacterial, parasite origin or tumor in a number of animal species including non-human primates and humans. Expand
Ginsenoside Rd elicits Th1 and Th2 immune responses to ovalbumin in mice.
Results suggested that Rd had immunological adjuvant activity, and elicited a Th1 or Th2 immune response by regulating production and gene expression of Th1 cytokines and Th2 cytokines. Expand
Relationship between haemolytic and adjuvant activity and structure of protopanaxadiol-type saponins from the roots of Panax notoginseng.
Four protopanaxadiol-type saponins isolated from the roots of Panax notoginseng were evaluated for their haemolytic activities and adjuvant potentials on the cellular and humoral immune responses of ICR mice against ovalbumin (OVA). Expand
Contribution of the glycidic moieties to the haemolytic and adjuvant activity of platycodigenin-type saponins from the root of Platycodon grandiflorum.
The results suggested that the number of sugar residues in the glycidic chains attached to C-3 of aglycone could affect the haemolytic and adjuvant activities of platycodigenin-type saponins, and that PD had immunological adjUvant activity, and simultaneously elicited a Th1 and Th2 immune response by regulating gene expression of Th1/Th2 cytokines and transcription factors. Expand
Antioxidant Capacity and Proanthocyanidin Composition of the Bark of Metasequoia glyptostroboides
- F. Chen, Lin Zhang, Shuling Zong, S. Xu, Xiaoyu Li, Y. Ye
- Medicine, Chemistry
- Evidence-based complementary and alternative…
- 17 March 2014
The fraction MGEB, which was obtained by 60% ethanol extraction and followed by a further separation with D101 resin column chromatograph, possessed the highest proanthocyanidin content and the highest free radical scavenging and antioxidant activities, and could significantly protect against CCl4 induced acute liver injury through inhibition of oxidative stress in mice. Expand
Stephanthraniline A inhibits the proliferation and activation of T cells in vitro and in vivo.
- F. Chen, Yang Ni, Y. Ye, H. Sun, Xiaoyu Li, Shifang Xu
- Biology, Medicine
- European journal of pharmacology
- 15 June 2012
The data indicate that STA inhibits the proliferation of T cells by inducing cell cycle arrest but not inducing apoptosis, and suggested the potential of the natural steroid STA as the effective candidate compounds for use in the treatment of inflammatory and autoimmune diseases. Expand
Structure and biological activity of protopanaxatriol-type saponins from the roots of Panax notoginseng.
The structure-activity relationship studies suggested that the number, the length and the position of sugar side chains, and the type of glucosyl group in the structure of PTS could not only affect their haemolytic activities and adjuvant potentials, but have significant effects on the nature of the immune responses. Expand