Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
- H. Su, Sheng Yao, Ye-chun Xu
- Chemistry, BiologyActa Pharmacologica Sinica
- 31 July 2020
Baicalin and baicalein, two ingredients of Shuanghuanglian, were characterized as the first noncovalent, nonpeptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.
- M. Tan, Ji‐Ming Ye, Y. Ye
- Chemistry, BiologyChemistry and Biology
- 21 March 2008
Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro
Baicalin and baicalein were identified as the first non-covalent, non-peptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Naturally occurring homoisoflavonoids and their pharmacological activities.
- Ligen Lin, Qianyu Liu, Y. Ye
- Biology, MedicinePlanta Medica
- 25 August 2014
The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge from phytochemical and pharmacological studies performed on homoisoflavonoids during the past decades.
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
The discovery of myricetin, a flavonoid found in many food sources, is described, as a non-peptidomimetic and covalent inhibitor of the SARS-CoV-2 3CLpro, highlighting the potential of pyrogallol as an alternative warhead in design of targeted covalant ligands.
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
Hematoxylin and its natural analogues were substantially validated to function as a new class of PTK inhibitors and showed good agreement with the result of concurrent molecular docking simulation.
Lignanamides and Sesquiterpenoids from Stems of Mitrephora thorelii
- F. Ge, Chunping Tang, Y. Ye
- Chemistry
- 1 June 2008
The first phytochemical investigation on stems of Mitrephora thorelii led to the isolation of three new lignanamides, thoreliamides A–C (1–3), and a new sesquiterpenoid, thorelinin (4), together with…
Anthraquinones, sterols, triterpenoids and xanthones from Cassia obtusifolia.
- Sylvain Valère T. Sob, H. K. Wabo, A. Tchinda, P. Tane, B. Ngadjui, Y. Ye
- Chemistry
- 1 June 2010
Dicarabrones A and B, a pair of new epimers dimerized from sesquiterpene lactones via a [3 + 2] cycloaddition from Carpesium abrotanoides.
- Jie-Wei Wu, Chunping Tang, Lan Chen, Yan Qiao, M. Geng, Y. Ye
- ChemistryOrganic Letters
- 20 March 2015
Dicarabrones A and B, a pair of epimers possessing a new skeleton featuring a cyclopentane ring connecting two sesquiterpene lactone units, were isolated from the whole plant of Carpesium…
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