Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients
Baicalin and baicalein, two ingredients of Shuanghuanglian, were characterized as the first noncovalent, nonpeptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway.
Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro
Baicalin and baicalein were identified as the first non-covalent, non-peptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Naturally occurring homoisoflavonoids and their pharmacological activities.
The main purpose of this review is to provide a comprehensive and up-to-date state of knowledge from phytochemical and pharmacological studies performed on homoisoflavonoids during the past decades.
Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease
The discovery of myricetin, a flavonoid found in many food sources, is described, as a non-peptidomimetic and covalent inhibitor of the SARS-CoV-2 3CLpro, highlighting the potential of pyrogallol as an alternative warhead in design of targeted covalant ligands.
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
Hematoxylin and its natural analogues were substantially validated to function as a new class of PTK inhibitors and showed good agreement with the result of concurrent molecular docking simulation.
Lignanamides and Sesquiterpenoids from Stems of Mitrephora thorelii
The first phytochemical investigation on stems of Mitrephora thorelii led to the isolation of three new lignanamides, thoreliamides A–C (1–3), and a new sesquiterpenoid, thorelinin (4), together with…
Anthraquinones, sterols, triterpenoids and xanthones from Cassia obtusifolia.
Dicarabrones A and B, a pair of new epimers dimerized from sesquiterpene lactones via a [3 + 2] cycloaddition from Carpesium abrotanoides.
Dicarabrones A and B, a pair of epimers possessing a new skeleton featuring a cyclopentane ring connecting two sesquiterpene lactone units, were isolated from the whole plant of Carpesium…