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Tandem duplication of mitochondrial DNA in the black-faced spoonbill, Platalea minor.
Mitochondrial (mt) heteroplasmy in the control region (CR) of the black-faced spoonbill was investigated using LA-PCR. To avoid amplification of transpositioned nuclear genome fragment from mtDNAExpand
Genetic structure of the asiatic black bear in Japan using mitochondrial DNA analysis.
The genetic structure of the Asiatic black bear (Ursus thibetanus) in Japan was studied to understand the events that occurred during its evolution. The left domain of the mitochondrial controlExpand
Current perspectives on the intensity of natural selection of MHC loci
Polymorphism of genes in the major histocompatibility complex (MHC) is believed to be maintained by balancing selection. However, direct evidence of selection has proven difficult to demonstrate. InExpand
MHC class II DQB diversity in the Japanese black bear, Ursus thibetanus japonicus
BackgroundThe major histocompatibility complex (MHC) genes are one of the most important genetic systems in the vertebrate immune response. The diversity of MHC genes may directly influence theExpand
Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies
We performed exome-wide association studies to identify genetic variants that influence systolic or diastolic blood pressure or confer susceptibility to hypertension in Japanese. The exome-wideExpand
Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease
Early-onset cardiovascular and renal diseases have a strong genetic component. In the present study, exome-wide association studies (EWASs) were performed to identify genetic variants that conferExpand
Identification of six polymorphisms as novel susceptibility loci for ischemic or hemorrhagic stroke by exome-wide association studies
In this study, we performed exome-wide association studies (EWASs) to identify genetic variants that confer susceptibility to ischemic stroke, intracerebral hemorrhage (ICH), or subarachnoidExpand
Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies
We have performed exome-wide association studies to identify single nucleotide polymorphisms that influence serum concentrations of triglycerides, high density lipoprotein (HDL)–cholesterol, or lowExpand
A human-specific allelic group of the MHC DRB1 gene in primates
BackgroundDiversity among human leukocyte antigen (HLA) molecules has been maintained by host-pathogen coevolution over a long period of time. Reflecting this diversity, the HLA loci are the mostExpand
A limit to the divergent allele advantage model supported by variable pathogen recognition across HLA‐DRB1 allele lineages
Abstract Genetic diversity in human leukocyte antigen (HLA) molecules is thought to have arisen from the co‐evolution between host and pathogen and maintained by balancing selection. HeterozygoteExpand
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