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An Endoplasmic Reticulum Stress-specific Caspase Cascade in Apoptosis
- N. Morishima, K. Nakanishi, Hiromi Takenouchi, T. Shibata, Y. Yasuhiko
- Biology, ChemistryThe Journal of Biological Chemistry
- 13 September 2002
The results suggest that caspase-12 can activate casp enzyme-9 without involvement of cytochrome c and that ER stress triggers a specific cascade involving caspasing-12, -9, and -3 in a cytochromec-independent manner.
Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression.
- Y. Yasuhiko, S. Haraguchi, S. Kitajima, Yu Takahashi, J. Kanno, Y. Saga
- BiologyProceedings of the National Academy of Sciences…
- 7 March 2006
The data reveal that a mechanism, via Tbx6-dependent Notch signaling, acts on the transcriptional regulation of Mesp2, and uncovers an additional component of the interacting network of various signaling pathways that are involved in somitogenesis.
Calmodulin binds to inv protein: Implication for the regulation of inv function
- Y. Yasuhiko, F. Imai, K. Ookubo, Y. Takakuwa, K. Shiokawa, T. Yokoyama
- BiologyDevelopment, growth & differentiation
- 1 December 2001
It is shown that calmodulin binds to mouse inv protein at two sites (IQ1 and IQ2), implying that the IQ2 site is essential for inv to randomize left–right asymmetry in Xenopus embryos, and proposed a model for the regulation of inv function by calcium–calmodulin.
Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.
Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2
There is significant evolutionary conservation of Mesp regulatory mechanisms between fish and mice, and enhancer analyses indicated that the number and spatial organization of the T-box binding sites are critical for initiating Mesp2 transcription via Notch signaling.
FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway.
It is suggested that FZD4S plays a role as a positive regulator of the WNT signaling pathway and seven-transmembrane-type FZd4 due to alternative splicing.
Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis
The compound heterozygosity of null mutations and the common risk haplotype in TBX6 also causes CS in Japanese patients with similar incidence, and may represent a spectrum of the same disease with TACS.
Isolation of Xenopus frizzled-10A and frizzled-10B genomic clones and their expression in adult tissues and embryos.
Results suggest that Xfz10 has important roles in neural tissue formation in Xenopus and in embryos, two mRNAs were equally expressed from the blastula stage with their peak expression at the late gastrula stage.
Tbx 6-mediated Notch signaling controls somite-specific Mesp 2 expression
The data reveal that a mechanism, via Tbx6dependent Notch signaling, acts on the transcriptional regulation of Mesp2, and uncovers an additional component of the interacting network of various signaling pathways that are involved in somitogenesis.
Transgenic analysis of the medaka mesp‐b enhancer in somitogenesis
This report identifies the essential enhancer element of medaka mesp‐b, an orthologue of mouse Mesp2, using transgenic techniques and embryo manipulation and demonstrates that a region of approximately 2.8 kb, upstream of the mesp •b gene, is responsible for both the initiation and anterior localization of mesp•b transcription within a somite primordium.