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The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers.
Adenosine-to-inosine (A-to-I) RNA editing is a widespread post-transcriptional mechanism, but its genomic landscape and clinical relevance in cancer have not been investigated systematically. WeExpand
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Exploratory analyses of efficacy data from major depressive disorder trials submitted to the US Food and Drug Administration in support of new drug applications.
OBJECTIVE There has been concern about a high rate of placebo response and a substantial failure rate in recent clinical trials in major depressive disorder (MDD). This report explores differences inExpand
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Evaluating link prediction methods
Link prediction is a popular research area with important applications in a variety of disciplines, including biology, social science, security, and medicine. The fundamental requirement of linkExpand
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Inferring user demographics and social strategies in mobile social networks
Demographics are widely used in marketing to characterize different types of customers. However, in practice, demographic information such as age, gender, and location is usually unavailable due toExpand
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ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways
There is increasing evidence that circular RNA (circRNA) are involved in cancer development, but the regulation and function of human circRNA remain largely unknown. In this study, we demonstratedExpand
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Expression of esophageal cancer related gene 4 (ECRG4), a novel tumor suppressor gene, in esophageal cancer and its inhibitory effect on the tumor growth in vitro and in vivo
The ECRG4 gene was initially identified and cloned in our laboratory from human normal esophageal epithelium (GenBank accession no. AF325503). We revealed the expression of ECRG4 protein wasExpand
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A perspective on medical infrared imaging
Since the early days of thermography in the 1950s, image processing techniques, sensitivity of thermal sensors and spatial resolution have progressed greatly, holding out fresh promise for infraredExpand
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Unveiling Distribution Patterns of Freshwater Phytoplankton by a Next Generation Sequencing Based Approach
The recognition and discrimination of phytoplankton species is one of the foundations of freshwater biodiversity research and environmental monitoring. This step is frequently a bottleneck in theExpand
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Depression increases the risk of hypertension incidence: a meta-analysis of prospective cohort studies
Background: It has long been known that depression is associated with hypertension but whether depression is a risk factor for hypertension incidence is still inconclusive. Objectives: To assessExpand
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A Practical Comparison of De Novo Genome Assembly Software Tools for Next-Generation Sequencing Technologies
The advent of next-generation sequencing technologies is accompanied with the development of many whole-genome sequence assembly methods and software, especially for de novo fragment assembly. Due toExpand
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