Y. Yang

Publications1,007
h-index78
Citations27,664
Highly Influential Citations931
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Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
The peritoneal cavity (PerC) is a unique compartment within which a variety of immune cells reside, and from which macrophages (MØ) are commonly drawn for functional studies. Here we define two MØ… Expand
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Kruppel-like Factor 4 (Klf4) Prevents Embryonic Stem (ES) Cell Differentiation by Regulating Nanog Gene Expression*
Transcription factor Kruppel-like factor 4 (Klf4) is essential for somatic cell reprogramming. In addition, Klf4 seems to play a redundant role along with other Klf family proteins in embryonic stem… Expand
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Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors
The NLRP3 inflammasome is a multimeric protein complex that initiates an inflammatory form of cell death and triggers the release of proinflammatory cytokines IL-1β and IL-18. The NLRP3 inflammasome… Expand
  • 224
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Division and differentiation of natural antibody-producing cells in mouse spleen
B-1a cells reside in both the peritoneal cavity and the spleen. LPS stimulates splenic B-1a to differentiate to plasma cells producing natural IgM specific for microbial and self antigens. However,… Expand
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Heparanase Stimulation of Protease Expression Implicates It as a Master Regulator of the Aggressive Tumor Phenotype in Myeloma*
High levels of heparanase are an indicator of poor prognosis in myeloma patients, and up-regulation of the enzyme enhances tumor growth, angiogenesis, and metastasis in animal models. At least part… Expand
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Oncomodulin links inflammation to optic nerve regeneration
  • Y. Yin, Q. Cui, +9 authors L. Benowitz
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 17 November 2009
The inflammatory response that accompanies central nervous system (CNS) injury can affect neurological outcome in both positive and negative ways. In the optic nerve, a CNS pathway that normally… Expand
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CNP is required for maintenance of axon–glia interactions at nodes of Ranvier in the CNS
Axoglial interactions underlie the clustering of ion channels and of cell adhesion molecules, regulate gene expression, and control cell survival. We report that Cnp1‐null mice, lacking expression of… Expand
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Recurrently deregulated lncRNAs in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) cells often invade the portal venous system and subsequently develop into portal vein tumour thrombosis (PVTT). Long noncoding RNAs (lncRNAs) have been associated with… Expand
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SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury.
Ischemia reperfusion (IR) injury (IRI) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. Silent information regulator 1 (SIRT1), a type of histone deacetylase,… Expand
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HSulf-1 and HSulf-2 Are Potent Inhibitors of Myeloma Tumor Growth in Vivo*
To participate as co-receptor in growth factor signaling, heparan sulfate must have specific structural features. Recent studies show that when the levels of 6-O-sulfation of heparan sulfate are… Expand
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