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Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis
- H. Nagai, Y. Okazaki, S. Toyokuni
- BiologyProceedings of the National Academy of Sciences
- 14 November 2011
It is proposed that different degrees of direct mesothelial injury by thin and thick MWCNTs are responsible for the extent of inflammogenicity and carcinogenicity, and suggested that control of the diameter of M WCNTs could reduce the potential hazard to human health.
Napsin A is a specific marker for ovarian clear cell adenocarcinoma
It is proposed that napsin A is another sensitive and specific marker for distinguishing ovarian clear cell tumors (especially adenocarcinomas) from other ovarian tumors.
ALK+, CD30−, CD20− Large B-Cell Lymphoma Containing Anaplastic Lymphoma Kinase (ALK) Fused to Clathrin Heavy Chain Gene (CLTC)
This case confirms the existence of ALK+, CD30−, CD20− large B-cell lymphomas proposed by Delsol et al. (16) and further provides relevant information regarding their clinicopathological features and cytogenetics.
Lack of presence of the human cytomegalovirus in human glioblastoma
HCMV is not persistent, at least in the tumor cells, of developed human glioblastoma, as the QPCR analysis could detect 10 copies of HCMV DNA mixed with DNA extracted from 104 H CMV-negative cells.
The Human Cytomegalovirus Gene Products Essential for Late Viral Gene Expression Assemble into Prereplication Complexes before Viral DNA Replication
The products of ORFs UL79, -87, and -95 were expressed as early viral proteins and recruited to prereplication complexes (pre-RCs) along with UL44, before the initiation of viral DNA replication.
Fenton Reaction Induced Cancer in Wild Type Rats Recapitulates Genomic Alterations Observed in Human Cancer
It is suggested that an iron-dependent Fenton chemical reaction causes large-scale genomic alterations during carcinogenesis, which may result in distinct genomic profiles in humans.
[Mechanisms of asbestos-induced carcinogenesis].
- S. Toyokuni, Li Jiang, Y. Yamashita
- MedicineNihon eiseigaku zasshi. Japanese journal of…
- 1 February 2009
In this review, the cutting edge results of the 5-year project funded by a MEXT grant are summarized, in which local iron deposition and the characteristics of mesothelial cells are the key issues.
Diffuse large B-cell lymphoma initially manifesting in the bone marrow.
DLBCL initially manifesting in the BM is considered to be a unique entity because the neoplastic cells proliferate mainly in BM, with infrequent involvement of the sinusoids and occasional leukemic infiltration in various organs.
Frequent expression of CD30 antigen in the primary gastric non‐B, non‐Hodgkin lymphomas
- Sachiko Iwamizu-Watanabe, Y. Yamashita, Y. Yatabe, Shigeo Nakamura, N. Mori
- Medicine, BiologyPathology international
- 1 July 2004
It is considered that some of the cases in the present study may be derived from cytotoxic T cells, similar to systemic and cutaneous ALCL, the majority of which exhibit TIA‐1.
Met Is the Most Frequently Amplified Gene in Endometriosis-Associated Ovarian Clear Cell Adenocarcinoma and Correlates with Worsened Prognosis
Targeted inhibition of the Met pathway may be a promising treatment for clear cell adenocarcinoma of the ovary, which is a chemo-resistant tumor with a relatively poor prognosis and frequently associated with endometriosis.