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Traces of Human Migrations in Helicobacter pylori Populations
Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations deriveExpand
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AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1
The Wnt signalling pathway is essential for development and organogenesis. Wnt signalling stabilizes β-catenin, which accumulates in the cytoplasm, binds to T-cell factor (TCF; also known asExpand
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An African origin for the intimate association between humans and Helicobacter pylori
Infection of the stomach by Helicobacter pylori is ubiquitous among humans. However, although H. pylori strains from different geographic areas are associated with clear phylogeographicExpand
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Relationship between Helicobacter pylori iceA, cagA, and vacA Status and Clinical Outcome: Studies in Four Different Countries
ABSTRACT There is continuing interest in identifying Helicobacter pylori virulence factors that might predict the risk for symptomatic clinical outcomes. It has been proposed thaticeA and cagA genesExpand
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Mechanisms of disease: Helicobacter pylori virulence factors
  • Y. Yamaoka
  • Medicine, Biology
  • Nature Reviews Gastroenterology &Hepatology
  • 1 November 2010
Helicobacter pylori plays an essential role in the development of various gastroduodenal diseases; however, only a small proportion of people infected with H. pylori develop these diseases. SomeExpand
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Variants of the 3′ Region of the cagA Gene inHelicobacter pylori Isolates from Patients with DifferentH. pylori-Associated Diseases
ABSTRACT The CagA protein of Helicobacter pylori is an immunogenic antigen of variable size and unknown function that has been associated with increased virulence as well as two mutually exclusiveExpand
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A M(r) 34,000 proinflammatory outer membrane protein (oipA) of Helicobacter pylori.
The complete genome sequence revealed a family of 32 outer membrane proteins (OMPs) in Helicobacter pylori. We examined the effect of four OMPs (HP0638, HP0796, HP1501, and babA2) on the productionExpand
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Importance of Helicobacter pylori oipA in clinical presentation, gastric inflammation, and mucosal interleukin 8 production.
BACKGROUND & AIMS Disease-associated virulence factors of Helicobacter pylori may not be independent of one another. The aim was to determine which H. pylori virulence factor(s) was the mostExpand
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Epidemiology of Helicobacter pylori Infection and Public Health Implications
This review summarizes studies on the epidemiology and public health implications of Helicobacter pylori published in peer‐reviewed journals from April 2010 through March 2011. Prevalence rates varyExpand
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Gain and Loss of Multiple Genes During the Evolution of Helicobacter pylori
Sequence diversity and gene content distinguish most isolates of Helicobacter pylori. Even greater sequence differences differentiate distinct populations of H. pylori from different continents, butExpand
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