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Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer.
NF-κB comprises a family of inducible transcription factors that serve as important regulators of the host immune and inflammatory response. In addition, NF-κB is also involved in protecting cells… Expand
The IKK NF-kappa B system: a treasure trove for drug development.
The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta.
NF-kappaB comprises a family of cellular transcription factors that are involved in the inducible expression of a variety of cellular genes that regulate the inflammatory response. NF-kappaB is… Expand
The IKK NF-κB system: a treasure trove for drug development
Nuclear factor-κB (NF-κB)/Rel transcription factors have been suspected since their discovery to play a pivotal role in chronic and acute inflammatory diseases. It now seems that aberrant regulation… Expand
Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression
Cytokine-induced activation of the IκB kinases (IKK) IKK-α and IKK-β is a key step involved in the activation of the NF-κB pathway. Gene-disruption studies of the murine IKK genes have shown that… Expand
IkappaB kinases: key regulators of the NF-kappaB pathway.
The nuclear factor (NF)-kappaB pathway is important for the expression of a wide variety of genes that are involved in the control of the host immune and inflammatory response, and in the regulation… Expand
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression.
Cytokine-induced activation of the IkappaB kinases (IKK) IKK-alpha and IKK-beta is a key step involved in the activation of the NF-kappaB pathway. Gene-disruption studies of the murine IKK genes have… Expand
Placenta Growth Factor and Vascular Endothelial Growth Factor B and C Expression in Microvascular Endothelial Cells and Pericytes
- H. Yonekura, S. Sakurai, +8 authors H. Yamamoto
- Biology, Medicine
- The Journal of Biological Chemistry
- 3 December 1999
We have shown previously that vascular endothelial growth factor (VEGF) synthesized by the cellular constituents of small vessels per se, viz.endothelial cells and pericytes, participates in the… Expand
Sulindac inhibits activation of the NF-kappaB pathway.
Sulindac is a non-steroidal anti-inflammatory agent that is related both structurally and pharmacologically to indomethacin. In addition to its anti-inflammatory properties, sulindac has been… Expand
The receptor for advanced glycation end products is induced by the glycation products themselves and tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through Sp-1…
- N. Tanaka, H. Yonekura, S. Yamagishi, H. Fujimori, Y. Yamamoto, H. Yamamoto
- The Journal of biological chemistry
The binding of advanced glycation end products (AGE) to the receptor for AGE (RAGE) is known to deteriorate various cell functions and is implicated in the pathogenesis of diabetic vascular… Expand